Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 299-682-2 | CAS number: 93893-89-1
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1973
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
- Type of study / information:
- study result
- Endpoint addressed:
- skin irritation / corrosion
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- human patch test on 60 volunteers
- GLP compliance:
- no
Test material
- Reference substance name:
- 3-methyl-5-phenylpent-2-enenitrile
- EC Number:
- 299-682-2
- EC Name:
- 3-methyl-5-phenylpent-2-enenitrile
- Cas Number:
- 93893-89-1
- Molecular formula:
- C12 H13 N
- IUPAC Name:
- (2E)-3-methyl-5-phenylpent-2-enenitrile
Constituent 1
Method
- Ethical approval:
- not specified
- Details on study design:
- Patches were applied to the probands' skin (sites on the backs and upper arms) for 24 h under occlusion.
- Exposure assessment:
- measured
- Details on exposure:
- TYPE OF EXPOSURE: patch test
TYPE OF EXPOSURE MEASUREMENT: Exposure pads
EXPOSURE LEVELS: 10 % suspension in olive oil
EXPOSURE PERIOD: 24 h
POSTEXPOSURE PERIOD: 72 h (observations were performed after 24, 48 and 72 hours)
Results and discussion
- Results:
- No signs of irriation were observed.
Applicant's summary and conclusion
- Conclusions:
- The test substance at a concentration of 10 % was not irritating to the skin.
- Executive summary:
The test material at a concentration of 10 % in olive oil was applied to skin sites on the backs and upper arms of 60 volunteers under occlusion. The patches were removed after 24 hours and skin reactions were observed 24, 48 and 72 hours thereafter. As a result, no skin reactions were recorded and thus it was concluded that the test substance was not irritating at a concentration of 10 %.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
