Registration Dossier
Registration Dossier
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EC number: 618-095-8 | CAS number: 879-57-2
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2000
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- 0.8
- Temp.:
- 40 °C
- pH:
- 3
- Details on results:
- The reference log Pow value in the OECD-guideline presumably refer to 25 °C. The column temperature was 40 °C. However, the influence of this temperature difference on the calculated log Pow value lies within the range of the error of this method. In order to comply with the demand of EG-guideline 92/69, the non-ionic form of the test substance and considering environmental relevance, pH 3 was chosen as pH value for the buffer.
- Conclusions:
- According to EU method A.8 a partition coefficient (log Pow) of 0.8 was determined for Imidoxim.
- Executive summary:
The partition coefficient was determined by using EU method A.8 (EG-guideline 92/69). In order to ensure a stable performance of the HPLC column, the column temperature was set to 40 °C.The reference log Pow values in the OECD-guideline presumably refer to 25 °C. However, the influence of this temperature difference on the calculated log Pow value lies within the range of the error of this method. In order to comply with the demand of EG-guideline 92/69, the nonionic form of the test substance and considering environmental relevance, pH3 was chosen as pH value for the buffer. The determined partition coefficient (log Pow) for Imidoxim is 0.8.
Reference
Description of key information
According to EU method A.8 a partition coefficient (log Pow) of 0.8 was determined for Imidoxim.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 0.8
- at the temperature of:
- 40 °C
Additional information
In order to ensure a stable performance of the HPLC column, the column temperature was set to 40 °C.The reference log Pow value in the OECD-guideline presumably refer to 25 °C. However, the influence of this temperature difference on the calculated log Pow value lies within the range of the error of this method.
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