Registration Dossier
Registration Dossier
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EC number: 203-467-0 | CAS number: 107-14-2
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VI
- Author:
- Smyth H.F.; Carpenter, C.P.; Weil C.S.; Pozzani, U.C.; Striegel, J.A.
- Year:
- 1 962
- Bibliographic source:
- American Industrial Toxicity Data: List VI 23: 95 - 107
- Reference Type:
- secondary source
- Title:
- American Industrial Hygiene Association
- Year:
- 1 962
- Bibliographic source:
- http://www.safe.nite.go.jp/english/ghs/11-mhlw-0074e.html Original source: American Industrial Hygiene Association Journal. Vol. 23, Pg. 95, 1962.
Materials and methods
- GLP compliance:
- no
- Test type:
- standard acute method
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- 2.5-3.5 kg body weight
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- The fur is removed from the entire trunk by clipping, and the dose is retained beneath an impervious plastic film.
The animals are immobilized during the 24-hour contact period, after which the film is removed and the rabbits are caged for the subsequent 14-day observation period. - Duration of exposure:
- 24 h
- Doses:
- Dosages greater than 20 ml/kg cannot be retained in contact with the skin.
- No. of animals per sex per dose:
- 4
- Control animals:
- not specified
- Statistics:
- Based upon mortalities during a 14-day observation period, the most probable LD50 value and its fiducial range are estimated by the method of Thompson using the tables of Weil.
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 0.071 mL/kg bw
- Remarks on result:
- other: equivalent to 84.4 mg/kg bw
- Mortality:
- Not specified
- Clinical signs:
- other: Not specified
- Gross pathology:
- Not specified
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 based on GHS criteria
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