Registration Dossier
Registration Dossier
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EC number: 272-028-3 | CAS number: 68649-42-3
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from Haz-Map, Databases
Data source
Reference
- Reference Type:
- other: authoritative database
- Title:
- Acute inhalation toxicity of test chemical
- Author:
- Jay A. Brown
- Year:
- 2 018
- Bibliographic source:
- Haz-Map Database 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- Acute inhalation toxicity study of Phosphorodithioic acid, O,O-di-C1-14-alkyl esters, zinc salts in rats
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Phosphorodithioic acid, O,O-di-C1-14-alkyl esters, zinc salts
- EC Number:
- 272-028-3
- EC Name:
- Phosphorodithioic acid, O,O-di-C1-14-alkyl esters, zinc salts
- Cas Number:
- 68649-42-3
- Molecular formula:
- C28H60O4P2S4Zn
- IUPAC Name:
- Dialkyl(C1-C14)dithiophosphoric acid, zinc salt
- Test material form:
- liquid
- Details on test material:
- - Name of test material (IUPAC name): Dialkyl(C1-C14)dithiophosphoric acid, zinc salt
- Common name: Phosphorodithioic acid, O,O–di–C1–14–alkyl esters, zinc salts
- Molecular formula: C28H60O4P2S4Zn
- Molecular weight: 716.38 g/mol
- Smiles notation: [Zn+2].CCCCCCCOP(=S)([S-])OCCCCCCC.CCCCCCCOP(=S)([S-])OCCCCCCC
- InChl: 1S/2C14H31O2PS2.Zn/c2*1-3-5-7-9-11-13-15-17(18,19)16-14-12-10-8-6-4-2;/h2*3-14H2,1-2H3,(H,18,19);/q;;+2/p-2
- Substance type: Organic
- Physical state: liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (IUPAC name): Dialkyl(C1-C14)dithiophosphoric acid, zinc salt
- Common name: Phosphorodithioic acid, O,O–di–C1–14–alkyl esters, zinc salts
- Molecular formula: C28H60O4P2S4Zn
- Molecular weight: 716.38 g/mol
- Smiles notation: [Zn+2].CCCCCCCOP(=S)([S-])OCCCCCCC.CCCCCCCOP(=S)([S-])OCCCCCCC
- InChl: 1S/2C14H31O2PS2.Zn/c2*1-3-5-7-9-11-13-15-17(18,19)16-14-12-10-8-6-4-2;/h2*3-14H2,1-2H3,(H,18,19);/q;;+2/p-2
- Substance type: Organic
- Physical state: liquid
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Analytical verification of test atmosphere concentrations:
- not specified
- Concentrations:
- 5,000 mg/m3
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- > 5 000 mg/m³ air
- Based on:
- test mat.
- Remarks on result:
- other: No mortality observed
- Mortality:
- No mortality were observed in treated rats at 5,000 mg/m3
- Clinical signs:
- other: not specified
- Body weight:
- not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- LC50 was considered to be > 5,000 mg/m3 when rats were exposed with Phosphorodithioic acid, O,O-di-C1-14-alkyl esters, zinc salts by inhalation.
- Executive summary:
In a acute inhalation toxicity study,rats were treated with Phosphorodithioic acid, O,O-di-C1-14-alkyl esters, zinc salts in the concentration of5,000 mg/m3by inhalation.No mortality was observed in treated rats at5,000 mg/m3. Therefore,LC50 was considered to be>5,000 mg/m3when rats were exposed with Phosphorodithioic acid, O,O-di-C1-14-alkyl esters, zinc salts by inhalation.
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