Registration Dossier
Registration Dossier
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EC number: 211-185-4 | CAS number: 632-79-1
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian germ cell study: gene mutation
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1993
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Reported by the U.S. National Toxicology Program and published in the peer reviewed literature.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Reference Type:
- publication
- Title:
- Chemical mutagenesis testing in Drosophilia. III. Results of 48 coded compouonds tested for the National Toxicology Program.
- Author:
- Valencia et al.
- Year:
- 1 985
- Bibliographic source:
- Environ. Mutagen 7, 325-348.
Materials and methods
- Principles of method if other than guideline:
- See Valencia et al. (1985) Environ. Mutagen 7, 325-348.
- GLP compliance:
- yes
- Type of assay:
- somatic mutation and recombination test in Drosophila
Test material
- Reference substance name:
- Tetrachlorophthalic anhydride
- EC Number:
- 204-171-4
- EC Name:
- Tetrachlorophthalic anhydride
- Cas Number:
- 117-08-8
- IUPAC Name:
- 4,5,6,7-tetrachloro-2-benzofuran-1,3-dione
- Details on test material:
- see rat and mouse 13 week studies
Constituent 1
Test animals
- Species:
- Drosophila melanogaster
- Strain:
- other: Canton-S wild-type
- Sex:
- male
Administration / exposure
- Route of administration:
- other: abdominal injection
- Vehicle:
- saline or peanut oil
- Duration of treatment / exposure:
- single injection
- Frequency of treatment:
- once
Doses / concentrations
- Remarks:
- Doses / Concentrations:
o, 500 ppm
Basis:
nominal conc.
- No. of animals per sex per dose:
- see Valencia et al. 1985
- Control animals:
- yes, concurrent vehicle
Examinations
- Tissues and cell types examined:
- see Valencia et al. 1985
Results and discussion
Test results
- Sex:
- male/female
- Genotoxicity:
- negative
- Toxicity:
- no effects
- Vehicle controls validity:
- valid
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results : negative
Tetrachlorophthalic anhydride, administered to males via abdominal injection, did not induce sex-linked recessive lethal mutations in the fruit fly. - Executive summary:
Tetrachlorophthalic anhydride, administered to males via abdominal injection, did not induce sex-linked recessive lethal mutations in the fruit fly.
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