Registration Dossier
Registration Dossier
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EC number: 421-720-5 | CAS number: 18085-02-4 3,4-DIACETOXY-1-BUTENE
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data migrated from NONS with permission to refer granted by ECHA.
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 92/69/EEC
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1,2-diacetoxybut-3-ene
- EC Number:
- 421-720-5
- EC Name:
- 1,2-diacetoxybut-3-ene
- Cas Number:
- 18085-02-4
- Molecular formula:
- C8H12O4
- IUPAC Name:
- 1-(acetyloxy)but-3-en-2-yl acetate
- Test material form:
- liquid
- Details on test material:
- No information on test material available. Endpoint study information provided by ECHA from migrated NONS data and specific information not included.
Constituent 1
- Specific details on test material used for the study:
- Colourless liquid
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 0.1 mL
- Number of animals or in vitro replicates:
- 3 rabbits
Results and discussion
In vivo
Results
- Irritation parameter:
- other: conjuctivae (redness), chemosis, cornea and iris scores.
- Basis:
- animal: 1, 2 and 3.
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Remarks:
- This is the data extracted from NONS notification dossier and provided by ECHA
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Information provided by ECHA indicates no irritation/corrosive effects in rabbit eyes.
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