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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data migrated from NONS with permission to refer granted by ECHA.

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
1996

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: 92/69/EEC
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2-diacetoxybut-3-ene
EC Number:
421-720-5
EC Name:
1,2-diacetoxybut-3-ene
Cas Number:
18085-02-4
Molecular formula:
C8H12O4
IUPAC Name:
1-(acetyloxy)but-3-en-2-yl acetate
Test material form:
liquid
Details on test material:
No information on test material available. Endpoint study information provided by ECHA from migrated NONS data and specific information not included.
Specific details on test material used for the study:
Colourless liquid

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White

Test system

Vehicle:
unchanged (no vehicle)
Amount / concentration applied:
0.1 mL
Number of animals or in vitro replicates:
3 rabbits

Results and discussion

In vivo

Results
Irritation parameter:
other: conjuctivae (redness), chemosis, cornea and iris scores.
Basis:
animal: 1, 2 and 3.
Time point:
24/48/72 h
Score:
0
Max. score:
0
Reversibility:
not specified
Remarks on result:
no indication of irritation
Remarks:
This is the data extracted from NONS notification dossier and provided by ECHA

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Information provided by ECHA indicates no irritation/corrosive effects in rabbit eyes.