Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

Currently viewing:

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data migrated from NONS with permission to refer granted by ECHA.

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
1996

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: 92/69/EEC
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2-diacetoxybut-3-ene
EC Number:
421-720-5
EC Name:
1,2-diacetoxybut-3-ene
Cas Number:
18085-02-4
Molecular formula:
C8H12O4
IUPAC Name:
1-(acetyloxy)but-3-en-2-yl acetate
Test material form:
liquid
Details on test material:
No information on test material available. Endpoint study information provided by ECHA from migrated NONS data and specific information not included.
Specific details on test material used for the study:
Colourless liquid

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White

Test system

Vehicle:
unchanged (no vehicle)
Amount / concentration applied:
0.1 mL
Number of animals or in vitro replicates:
3 rabbits

Results and discussion

In vivo

Results
Irritation parameter:
other: conjuctivae (redness), chemosis, cornea and iris scores.
Basis:
animal: 1, 2 and 3.
Time point:
24/48/72 h
Score:
0
Max. score:
0
Reversibility:
not specified
Remarks on result:
no indication of irritation
Remarks:
This is the data extracted from NONS notification dossier and provided by ECHA

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Information provided by ECHA indicates no irritation/corrosive effects in rabbit eyes.