Registration Dossier
Registration Dossier
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EC number: 306-523-3 | CAS number: 97281-24-8
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
No effects to activated sludge microorganisms.
Key value for chemical safety assessment
Additional information
Since no studies investigating the toxicity of Fatty acids, C8-10 (even numbered), diesters with neopentyl glycol and di- and triesters with trimethylolpropane (CAS 97281-24-8) to activated sludge microorganisms are available, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read-across to the structurally related source substances Fatty acids, C8-10 (even numbered), di-and triesters with propylidynetrimethanol (CAS 11138-60-6) and Heptanoic acid, ester with 2,2-dimethyl-1,3-propanediol (CAS 68855-18-5) was conducted. This read-across is justified in detail in the overall summary (IUCLID Section 6.1) and within the analogue justification in IUCLID Section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment.
The first study with the source substance Fatty acids, C8-10 (even numbered), di-and triesters with propylidynetrimethanol (CAS 11138-60-6) was conducted according to OECD 209 (GLP) using domestic activated sludge. The respiration inhibition was investigated and did not result in an inhibition but in an increase in respiration of 43% at the nominal tested concentration of 10000 mg/L compared to the control. Thus, an EC50 and EC10 (3 h) of > 10000 mg/L (nominal) were derived.
The second study with the source substance Heptanoic acid, ester with 2,2-dimethyl-1,3-propanediol (CAS 68855-18-5) did not cause inhibition of respiration of domestic activated sludge either. This study was performed according to OECD 209 (GLP). Since no effects were recorded the NOEC (3 h) was reported to be ≥ 1000 mg/L.
Based on the available results from structurally related source substances (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which are characterized by a similar ecotoxicological profile and comparable structure and the supporting result for the target substance itself, it can be concluded that Fatty acids, C8-10 (even numbered), diesters with neopentyl glycol and di- and triesters with trimethylolpropane will not inhibit the biodegradation process in sewage treatment plants.
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