Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 309-879-8 | CAS number: 101316-76-1 A complex combination of hydrocarbons obtained by fractionation from hydrodesulphurised coker distillate. It consists predominantly of hydrocarbons having carbon numbers predominantly in the range of C5 to C11 and boiling in the range of approximately 23°C to 196°C (73°F to 385°F).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- 1985
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented study report equivalent or similar to OECD guideline 405. GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 86290-81-5
- Cas Number:
- 86290-81-5
- IUPAC Name:
- 86290-81-5
- Reference substance name:
- Premium unleaded gasoline
- IUPAC Name:
- Premium unleaded gasoline
- Test material form:
- other: low viscosity liquid hydrocarbon
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Alpine Rabbitry
-Sex/number: 12 females
- Age at study initiation: Approximately 12 weeks old
- Weight at study initiation: 1.7-2.3 kg
- Housing: individually
- Diet (e.g. ad libitum): Purina rabbit chow, ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 20 days
ENVIRONMENTAL CONDITIONS
- Temperature (°F): 65-76 °F
- Humidity (%): 31 to 61 percent relative humidity
- Photoperiod (hrs dark / hrs light): 12hrs dark /12 hrs light
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 0.1ml
- Duration of treatment / exposure:
- 0.1 mL of the test article in a tuberculin syringe was dripped onto the surface of the right eye. The upper and lower lids were held closed for 1 -2 seconds
- Observation period (in vivo):
- Eyes were examined at prescreen, 24, 48, and 72 hours and day 4 following test article administration.
- Number of animals or in vitro replicates:
- 12 females
- Details on study design:
- The right eye of each rabbit was treated in the following manner. The animal was removed from the cage and physically restrained. At this time 0.1 mL of the test article in a tuberculin syringe was dripped onto the surface of the right eye. The upper and lower lids were held closed for 1 -2 seconds. Six of the animals were not treated further. The test eyes of the remaining 6 animals were flushed for approximately 1 minute with lukewarm water beginning approximately 20 -30 seconds after dosing. The left eye remained untreated and served as a control eye.
Observations of ocular lesions were made at 24, 48, and 72 hours, and day 4. The eyes were examined and scored according to the Draize system (Draize, J.H., et al., 1965). In addition, flourescein examination of all eyes were made at prescreen, 24, 48, 72 hours and day 4.
All animals were sacrificed following the day 4 scoring period.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- 6 animals
- Time point:
- other: 24, 48, and 72 hr average
- Score:
- ca. 0.2
- Max. score:
- 0.3
- Reversibility:
- fully reversible within: 72 hrs
- Remarks on result:
- other: unrinsed; max score at 24 and 48 hr; max possible score of 110
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- mean
- Remarks:
- 6 animals
- Time point:
- 24/48/72 h
- Score:
- ca. 0.06
- Max. score:
- 0.33
- Reversibility:
- fully reversible within: 4 days
- Remarks on result:
- other: unrinsed; max score at 72 hrs; max possible score of 3
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- 6 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- fully reversible
- Remarks on result:
- other: unrinsed; max possible score of 4
- Irritation parameter:
- cornea opacity score
- Remarks:
- opacity
- Basis:
- mean
- Remarks:
- 6 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- fully reversible
- Remarks on result:
- other: unrinsed; max possible score of 4
- Irritation parameter:
- iris score
- Remarks:
- lesion
- Basis:
- mean
- Remarks:
- 6 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- fully reversible
- Remarks on result:
- other: unrinsed; max possible score of 2
- Other effects:
- Premium unleaded gasoline (F-64-01) was also instilled into the eyes of 6 rabbits, which were rinsed 20-30 seconds after dosing. This method is not in compliance with OECD TG 405 and is not appropriate for classification purposes. The overall irritation score was 0 (max score out of 110 possible). The mean (24, 48, and 72 hr average) conjunctivae redness, chemosis, corneal opacity, and iris lesion scores were 0, 0, 0, and 0, respectively.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The mean corneal opacity, iris lesion, conjunctivae redness, and chemosis scores were 0, 0, 0.06, and 0, respectively. These findings do not warrant classification of premium unleaded gasoline (F-64-01) as an ocular irritant under Regulation (EC) 1272/2008 on classification, labeling, and packaging of substances and mixtures (CLP) or under the Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparations.
- Executive summary:
Premium unleaded gasoline (F-64-01) was administered to one eye of six New Zealand White rabbits to assess for ocular irritation. Observations were made at 24, 48 and 72 hours and 4 days after treatment. Ocular damage was assessed and scored according to the Draize eye test. Ocular irritation was most prominent at the 48 and 72 hour observation period receiving a Draize score of 0.3. Irritation subsided and all animals were clear of ocular irritation within 4 days after treatment. The mean corneal opacity, iris lesion, conjunctivae redness, and chemosis scores were 0, 0, 0.06, and 0, respectively. These findings do not warrant classification of premium unleaded gasoline (F-64-01) as an ocular irritant under Regulation (EC) 1272/2008 on classification, labeling, and packaging of substances and mixtures (CLP) or under the Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.