1H-Imidazole, 5,5'-[1,1'-biphenyl]-4,4'-diylbis[2-(2S)-2-pyrrolidinyl-, hydrochloride (1:4)

Guidance on Safe Use

First-aid measures

Eye contact Rinse immediately with plenty of water for at least 15 minutes.  Keep eye wide open  while rinsing.  Obtain medical attention.  

Skin contact  IF ON SKIN: Wash with plenty of soap and water.  If skin irritation or rash occurs, seek medical advice/attention.  Wash contaminated        clothing before re-use.  

Inhalation Move to fresh air.  Oxygen or artificial respiration if needed.  Obtain medical attention

Ingestion Obtain medical attention.  Do NOT induce vomiting.  Never give anything by mouth to an unconscious person

Notes to Physician Material not fully tested.  Refer to Section 11.  Pregnant or nursing women should avoid exposure.  

Medical Surveillance Employees who are pregnant, are breast-feeding, or who are concerned with other reproductive issues should be encouraged to consult with the occupational health physician monitoring worker's health.  

Other information Precautionary risk management may be different from the exposure categories in the annex.  

Fire-fighting measures

Extinguishing Media  Suitable extinguishing media:  Dry chemical, Water spray, Foam.  Unsuitable extinguishing media:  Do NOT use water jet.

Protection of Firefighters  

Protective equipment:  Use personal protective equipment.  In the event of fire, wear self-contained breathing apparatus.  

Hazardous Combustion Products:  carbon oxides (COx), nitrogen oxides (NOx), gaseous hydrogen chloride (HCl).

Further Information:  HCl gas can form flammable or explosive mixtures with alcohols or metals.  In the event of fire and/or explosion do not breathe fumes.  

Other information Avoid generating dust; fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a               potential dust explosion hazard.

Decontaminate protective clothing and equipment before reuse.  Heating can releashazardous gases.  

Accidental release measures

Prsonal precautions:.  Use personal protective  equipment.  Examples include tightly fitting      safety goggles, lab coat and impervious gloves.  Wear respiratory protection.  Depending on the nature of the spill (quantity and extent of spill)           additional protective clothing and equipment such as a self-contained breathing apparatus may be needed.  

Environmental precautions   Prevent release to drains and waterways.  Prevent release to the environment.  

Containment Methods  Wet down any dust to prevent generation of aerosols, if appropriate.  Cover with suitable material.  

Cleanup Methods  Contain and collect spillage and place in container for disposal according to local  regulations .  Use a HEPA vacuum or moisten     materials to minimize dust generation during pick-up.  Clean area with detergent and water after spill pick-up, if appropriate.  Handle waste materials, including gloves, protective clothing, contaminated spill cleanup material, etc., as appropriate for chemically and pharmacologically similar materials.

Other information Dust deposits should not be allowed to accumulate on surfaces, as these may form an explosive mixture if they are released into    the atmosphere in sufficient concentration.  Avoid dispersal of dust in the air (i.e., clearing dust surfaces with compressed air).  Nonsparking tools should be used.  

   

Handling and storage

Handling Precautions  Avoid exposure - obtain special instructions before use.  Avoid formation of dust and  aerosols.  Keep away from heat and        sources of ignition.  Prevent release to drains and waterways.  

Minimize dust generation and accumulation.  Routine housekeeping should be instituted to ensure that dusts do not accumulate on surfaces.  Dry      powders can build static electricity charges when subjected to the friction of transfer and mixing operations.  Provide adequate precautions, such as electrical grounding and bonding, orinert atmospheres.  

Container Requirements   Do not store in metal containers.  Store in sturdy containers appropriate to maintain the integrity of this material for its        intended use.  

Storage Conditions  Store at room temperature.  Protect against light.  Keep away from heat, sparks and flames.

Transport information

Shipping

SpecialProvisions

Shipping

Remarks

Marine transport (UN RTDG/IMDG)

Shipping

Remarks

Shipping

Remarks

SpecialProvisions

Exposure controls / personal protection

Engineering Controls and  Ventilation

Use process enclosures, containment technology, or other engineering controls to keep airborne levels below recommended exposure limit.

When handling quantities up to 15 milligrams, a standard laboratory with general laboratory dilution ventilation (e.g. 6-12 air changes per hour) is

appropriate.  When handling quantities from 15 milligrams to 1 kilogram, work in a standard laboratory using a fume hood, biological safety

cabinet(Class II, all types), or approved vented enclosure.  Quantities exceeding 1 kilogram should be handled in a designated laboratory.  A

laminar flow/powder containment booth is recommended for handling >1 kilograms of active substance.  For manufacturing and pilot plant

operations, use direct coupling and closed transfer systems for all bulk transfers. Use dust tight valves as appropriate.  HEPA filtration of local

exhaust ventilation (LEV) is required.  It is recommended that all dust control equipment such as local exhaust ventilation and material transport

systems involved in handling of this product contain explosion relief vents or an explosion suppression system or an oxygen deficient environment.

Ensure that dust-handling systems (such as exhaust ducts, dust collectors, vessels, and processing equipment) are designed in an manner to            prevent the escape of dust into the work area (i.e., there is no leakage from the equipment).  Use only appropriately classified electrical equipment and

powered industrial trucks.  

Respiratory protection

Use and selection of respiratory protection is based upon engineering controls in use and potential for aerosol generation.  When engineering

controls are not sufficient control exposure, wear an approved respirator with NIOSH Class 100 or high efficiency particulate (HEPA) filters or

cartridges (EN 140/EN 136) when exposures are up to 10 times the exposure control guideline.   Wear a loose-fitting (Tyvek or helmet type)

HEPA powered-air purifying respirator (PAPR) (EN 12941) when exposures are 10-25 times the exposure control guideline.   Wear a full

facepiece negative pressure respirator with Class 100 or HEPA filters (EN 136) when exposures are 25-50 times the exposure control guideline.  

Wear a tight-fitting, full facepiece HEPA PAPR (EN 12942) when exposures are 50-100 times the exposure control guideline.   Wear a hoodshroud

HEPA PAPR(EN12941)or full facepiece supplied air respirator (EN 139) operated in a pressure demand or other positive pressure mode when                exposures are 100-1000 times the exposure control guideline.  

Eye Protection:

Safety glasses with side-shields are recommended (EN 166).    Face  shields or chemical safety goggles (EN 166) may be required if splash potential    exists or if corrosive materials are present.   Note: Choice of eye protection may be influenced by the type of respirator which is selected.  

Skin and Body Protection:

Wear a laboratory coat (EN 340) when handling quantities up to 1 kilogram.  For quantities over 1 kilogram, wear laboratory coat(EN 340)or

coverall of low permeability (EN 1149-1).  For manufacturing operations, wear coverall of low permeability (EN 465/1149-1).  For manufacturing

operations, wear coverall of low permeability (EN 1149-1).  

Hygiene

Wash hands and face before breaks and immediately after handling the  product.  

Environmental exposure controls Prevent release to drains and waterways.  

Stability and reactivity

Chemical Stability  Stable under normal conditions.  

Conditions to avoid  Not available

Materials to avoid Stainless steel  

Hazardous decomposition  products

Hazardous decomposition products formed under fire conditions.: carbon oxides (COx), nitrogen oxides (NOx), gaseous hydrogen chloride (HCl).

Hazardous reactions Not available

Explosion Severity St 1 (assumed)

Material exhibits weak to moderate explosion characteristics if ignited as a dust cloud.

Minimum Ignition Energy > 500 mJ  Material has low sensitivity to ignition as a dust cloud.  

Volume Resistivity (ambient) 9.5E+09 ohm.m

Material is moderately susceptible to accumulating static charges durinprocessing.

Charge decay time (ambient)  0.2 sec

Ignition temperature > 600 °C    

Layer decomposition  Material begins to exhibit exothermic activity at a temperature of: 217 - 249 °C.  Maintain maximum process temperatures at     least 20 °C below this onset temperature.

Disposal considerations

Advice On Disposal And Packaging Disposal should be in accordance with applicable regional, national and  local laws and regulations.                Local regulations may be more stringent than regional or national requirements.  This information presented only applies to the material as supplied.