Reaction products of 1-(substitutedphenyl)urea coupled with diazotated potassium sodium substituted-5-{[2-(substituted)ethyl]sulfonyl}benzenesulfonate, further condensed with 2,4,6-trichloro-1,3,5-triazine, further converted with disubstituted benzene-1,4-disulfonic acid in aq. sodium hydroxide

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

The study was conducted between 29 September 2015 and 24 February 2016

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Key result

Water solubility:

148 g/L

Conc. based on:

test mat.

Temp.:

20 °C

pH:

>= 5.7 - <= 6.2

Remarks on result:

other: very soluble

Details on results:

Preliminary Test
In the range greater than 5.1 % w/w of solution but less than 24.8 % w/w of solution at 20.0 ± 0.5 °C.

Definitive Test
Mean Concentration: 148 g/L at 20.0 ± 0.5 ºC
Standard Deviation: 3.75 g/L
Relative Standard deviation: 2.54 %

Preliminary Test

The sample concentration, observations and solution pH for each sample are shown in the following table:

Sample	Concentration (% w/w)	Observations	Solution pH
1	5.1	Deep orange colored solution. No excess undissolved test item.	5.8
2	24.8	Deep orange colored solution, with much excess undissolved test item.	*
3	49.8	Wet test item, plus much dry test item.	*
4	75.2	Wet test item, plus much dry test item.	*
5	94.8	Small amount of wet test item, plus much dry test item	*

*Not performed, due to lack of solution phase.

Definitive Test

The mean total peak areas relating to the standard and sample solutions are shown in the following table:

Solution	Mean total peakarea
Standard 100 mg/L	2.0794 x 10^7
Standard 100 mg/L	2.0395 x 10^7
Matrix Blank	None detected
Sample 1	3.1113 x 10^7
Sample 2	3.0497 x 10^7
Sample 3	2.9579 x 10^7

The concentration (g/L) of test item in the sample solutions is shown in the following table:

Sample number	Time shaken at ~ 30 ºC (hours)	Time equilibrated at 20 ºC (hours)	Concentration (g/L)	Solution pH
1	24	24	151	6.2
2	48	24	148	5.9
3	72	24	144	5.7

Validation

The linearity of the detector response with respect to concentration was assessed over the nominal concentration range of 25 to 200 mg/L (n = 6). The results were satisfactory with a correlation coefficient (r²) of 0.9999 being obtained.

Conclusions:

Interpretation of results (migrated information): very soluble (> 10000 mg/L)
The water solubility of the test item has been determined to be 148 g/L of solution at 20.0 ± 0.5 °C.

Executive summary:

Water Solubility. 148 g/L of solution at 20.0 ± 0.5 °C, using the flask method, designed to be compatible with Method A6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.

Description of key information

The Water Solubility of the test item was found determined to be 148 g/L of solution at 20.0 ± 0.5 °C, using the flask method.

Key value for chemical safety assessment

Water solubility:

148 g/L

at the temperature of:

20 °C

Additional information

The Water Solubility of the test item was found determined to be 148 g/L of solution at 20.0 ± 0.5 °C, using the flask method.