Registration Dossier
Registration Dossier
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EC number: 258-110-1 | CAS number: 52697-38-8
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The short-term toxicity to fish was evaluated based on a weight-of-evidence approach. Four studies were taken into account to assess the toxicity to fish.
- A 96-h LC50 of the test substance to rainbow trout (Oncorhynchus mykiss) was determined to be 59 mg/L (nominal) in an OECD 203 study. The test concentrations were 56 - 560 mg/L. The study is well documented but does not give evidence on the substance´s purity and/or composition.
- A 48-h LC50 of the test substance to rainbow trout (Oncorhynchus mykiss) was determined to be 22 mg/L (nominal) in an OECD precursor study. The test concentrations were 12.5 - 200 mg/L. The study is poorly documented and does not give evidence on the substance´s purity and/or composition.
- A 96-h LC50 of the test substance to zebrafish (Danio rerio) was determined to be >100 mg/L (nominal) in an OECD precursor study performed as limit test (100 mg/L). The study is poorly documented but gives evidence on the substance´s purity.
- A 96-h LC50 of the test substance to zebrafish (Danio rerio) was determined to be 566 mg/L (nominal) in an OECD precursor study. The test concentrations were 100 - 1000 mg/L. The study is moderately documented and gives evidence on the substance´s purity. The documented purity of this test is the highest amongst all studies.
The 96-h LC50 of 566 mg/L to Danio rerio was the most precise value due to the highest substance purity reported. The other study conducted with Danio rerio has a reported substance purity which is lower. The studies conducted with Oncorhynchus mykiss have no information about the substance purity and are therefore considered less reliable. It cannot be excluded that significant amounts of dispersing agents were used to artificially enhance solubility and exposure. Moreover, cold water fish species are scientifically less reliable in terms of toxicity prediction. Cold water species are subject to a circannual rhythm with different physiological conditions and varying fitness conditions. Therefore, a warm water species evidentially provides a better predictability of toxicity under laboratory conditions. Given that other aquatic species do not show any signs of toxicity up to the limit of water solubility (0.02 mg/L, OECD 105), no short-term toxicity to fish is expected at realistic exposure concentrations. Conclusively, the 96 -h LC50 of 566 mg/L clearly shows that the test item is not acutely toxic to fish up to the limit of water solubility and far beyond.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 566 mg/L
Additional information
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