Registration Dossier
Registration Dossier
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EC number: 228-504-8 | CAS number: 6283-92-7
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEC
- 600 mg/m³
- Study duration:
- subacute
- Species:
- rat
- Quality of whole database:
- Based on tests with shorter chain alkyl lactates.
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- NOAEC
- 75 mg/m³
- Study duration:
- subacute
- Species:
- rat
- Quality of whole database:
- Based on tests with shorter chain alkyl lactates.
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 500 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
- Quality of whole database:
- Low (not assignable).
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Study duration:
- subacute
- Species:
- rat
- Quality of whole database:
- Low (not assignable).
Additional information
Justification for classification or non-classification
The effect concentration for an analogue of alkyl lactates ( 2-ethylhexyl-L-lactate) was above the classification limit of 0.2 mg/L (> 200 mg/m³) for inhalatory exposure of aerosol or mist. Local effects of repeated respiratory exposure to a concentration of 75 mg/m³ included slight focal hyperplasia of the nasal respiratory epithelium, including hyperplasia of goblet cells. In case of dermal exposure, the effect concentration for an analogue of alkyl lactates (Cetyl lactate) was above the classification limit of 200 mg/kg bw/d (> 500 mg/kg bw/d).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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