Registration Dossier
Registration Dossier
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EC number: 246-919-2 | CAS number: 25377-82-6
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
A measured BCF is not available for alkenes C11/13/14. Log BCF have been calculated using two QSAR for dodecene and tetradecene. Calculated log BCF range from 2.26-4.66.
Key value for chemical safety assessment
Additional information
A measured BCF is not available for alkenes C11/13/14. As based on read across their mesaured log Kow is >3 the bioaccumulation endpoint cannot be waived. However, ECHA's Guidance on Information Requirements and Chemical Safety Assessment R7c Endpoint Specific Guidance (2008) indicates that before commissioning a new vertebrate test alternative sources of data on the bioaccumulation potential of a chemical should used.
Nonpolar substances have been shown to have a linear relationship between log Kow and BCF in the log Kow range 1 -6, and a parabolic relationship at log Kow >6. Several QSAR have been developed that calculate the BCF of non-polar, hydrophobic compounds on the basis of their log Kow (e.g. Connell and Hawker, 1988 and USEPA, 2008). Dodecene and tetradecene fall within the applicability domains of these models and the calculated values are read across to alkenes C11/13/14. The calculated log BCF range from 2.26 -4.66, indicating that alkenes C11/13/14 may bioaccumulate or pose a risk of secondary poisoning.
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