2,2'-phenyliminodiethanol

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Animal experimental study, predates implementation of GLP and/or development of study guidelines, limitations in design and/or reporting but otherwise adequate for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1974

Report date:

1974

Materials and methods

Principles of method if other than guideline:

According to BASF-internal standard: Five Sprague-Dawley rats per sex per dose were exposed to the test substance dissolved in carboxymethyl cellulose (with 2-3 drops Cremophor EL) via oral gavage. Animals received 1600, 3200, 4000 and 6400 mg/kg bw. After an observation of 7 days animals were necropsied.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2,2'-phenyliminodiethanol

EC Number:

204-368-5

EC Name:

2,2'-phenyliminodiethanol

Cas Number:

120-07-0

Molecular formula:

C10H15NO2

IUPAC Name:

2-[(2-hydroxyethyl)(phenyl)amino]ethan-1-ol

Details on test material:

- Name of test material (as cited in study report): Dioxyäthyl-anilin

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

- Weight at study initiation: Males: 143 - 169g; Females: 142 - 167g

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

CMC (carboxymethyl cellulose)

Remarks:

with 2-3 drops Cremophor EL

Details on oral exposure:

The test substance was administered in concentrations of 2, 16 and 30%

Doses:

1600, 3200, 4000 and 6400 mg/kg

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

- Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

ca. 3 400 mg/kg bw

Based on:

test mat.

Mortality:

- 1600 mg/kg: no deaths observed
- 3200 mg/kg: 3/5 females died within 24 hours. 0/5 males died within 7 days
- 4000 mg/kg: 1/5 females died within 1 hour, the remaining females died within a day. 2/5 males died within 24 hours, 4/5 males were dead after 7 days.
- 6400 mg/kg: 4/5 females and 2/5 males died within 1 hours, the remaining animlas died within a day

Clinical signs:

other: Immediately after application until 20 minutes after application dyspnea, partly atony and staggering, narcotic-like state, scretion from snounts was observed. All symptoms were absent within 5 days.

Gross pathology:

Acute heart dilatation and congestive hyperemia, dilated stomach with liquid content, diarrheic intestine content, splenomegaly were observed.

Applicant's summary and conclusion

Interpretation of results:

practically nontoxic

Remarks:

Migrated information