Registration Dossier
Registration Dossier
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EC number: 204-368-5 | CAS number: 120-07-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Animal experimental study, predates implementation of GLP and/or development of study guidelines, limitations in design and/or reporting but otherwise adequate for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
- Principles of method if other than guideline:
- According to BASF-internal standard: Five Sprague-Dawley rats per sex per dose were exposed to the test substance dissolved in carboxymethyl cellulose (with 2-3 drops Cremophor EL) via oral gavage. Animals received 1600, 3200, 4000 and 6400 mg/kg bw. After an observation of 7 days animals were necropsied.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2,2'-phenyliminodiethanol
- EC Number:
- 204-368-5
- EC Name:
- 2,2'-phenyliminodiethanol
- Cas Number:
- 120-07-0
- Molecular formula:
- C10H15NO2
- IUPAC Name:
- 2-[(2-hydroxyethyl)(phenyl)amino]ethan-1-ol
- Details on test material:
- - Name of test material (as cited in study report): Dioxyäthyl-anilin
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Weight at study initiation: Males: 143 - 169g; Females: 142 - 167g
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Remarks:
- with 2-3 drops Cremophor EL
- Details on oral exposure:
- The test substance was administered in concentrations of 2, 16 and 30%
- Doses:
- 1600, 3200, 4000 and 6400 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 3 400 mg/kg bw
- Based on:
- test mat.
- Mortality:
- - 1600 mg/kg: no deaths observed
- 3200 mg/kg: 3/5 females died within 24 hours. 0/5 males died within 7 days
- 4000 mg/kg: 1/5 females died within 1 hour, the remaining females died within a day. 2/5 males died within 24 hours, 4/5 males were dead after 7 days.
- 6400 mg/kg: 4/5 females and 2/5 males died within 1 hours, the remaining animlas died within a day - Clinical signs:
- other: Immediately after application until 20 minutes after application dyspnea, partly atony and staggering, narcotic-like state, scretion from snounts was observed. All symptoms were absent within 5 days.
- Gross pathology:
- Acute heart dilatation and congestive hyperemia, dilated stomach with liquid content, diarrheic intestine content, splenomegaly were observed.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information
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