Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 944-561-8 | CAS number: 1465004-85-6
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 02/04/2014 – 14/04/2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted in compliance with GLP and EU guideline, available as unpublished report, no restrictions, fully adequate for assessment.
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Chilworth Technology Limited, Beta House, Southampton Science Park, Southampton SO16 7NS, United Kingdom
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 2.4
- pH:
- >= 8.03 - <= 8.94
- Remarks on result:
- other: Temperature was kept constant (+/-1°C) between 20-25°C
- Details on results:
- - Preliminary estimation: log Pow = 1.301. Test material is relatively non-polar. Such materials have a tendency of forming of microemulsion when dissolved in polar solvents. The test was performed visually hence effect of micro-emulsion must be considered in interpreting the estimated Log Pow.
- Formal Partition Coefficient Analysis: mean log Pow = 2.403. A whitish layer was observed at the octanol/water interface in every flask. The reason for the white layer could not be determined. Possible sample loss at the octanol-water interface must be considered when interpreting the test result. - Conclusions:
- The partition coefficient of the test substance between n-octanol and aqueous phase is 2.4 (log Pow).
- Executive summary:
In a study performed according to EU Method A8 and GLP, the partition coefficient of the test substance between n-octanol and aqueous phase was determined using the shake-flask method. The partition coefficient of the test substance between n-octanol and aqueous phase was determined to be 2.4 (log Pow).
Reference
Description of key information
In a study performed according to EU Method A8 and GLP, the partition coefficient of the test substance between n-octanol and aqueous phase was determined using the shake-flask method. The partition coefficient of the test substance between n-octanol and aqueous phase was determined to be 2.4 (log Pow).
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 2.4
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
