Registration Dossier
Registration Dossier
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EC number: 226-420-6 | CAS number: 5397-31-9
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: basic information given, no relevant route of exposure
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 963
- Report date:
- 1963
Materials and methods
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 3-(2-ethylhexyloxy)propylamine
- EC Number:
- 226-420-6
- EC Name:
- 3-(2-ethylhexyloxy)propylamine
- Cas Number:
- 5397-31-9
- Molecular formula:
- C11H25NO
- IUPAC Name:
- 3-[(2-ethylhexyl)oxy]propan-1-amine
- Details on test material:
- Name of the test substance used in the study report: 2-Ethylhexoxypropylamin; pH: ca. 12
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: "Tuebinger" mice
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Details on exposure:
- Aqueous emulsion with Traganth.
Test concentrations used: 0.5 and 2% (V/V) - Doses:
- 32, 40, 50, 100 and 200 mm3/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 resp. 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 25 mg/kg bw
- Remarks on result:
- other: original value: ca. 30 mm3/kg
- Mortality:
- 32 mm3/kg: 3/5 after 14 days; 40 mm3/kg: 4/5 after 14 days; 50 mm3/kg: 5/5 after 14 days; 100 and 200 mm3/kg: 5/5 after 7 days
- Clinical signs:
- Immediately after injection restlessness, accelerated breathing and - in the higher dose levels - atony and jumping convulsions; thereafter gasping and normal behaviour. After 2 - 3 days deterioration of the general state: shaking movements, staggering and clotty eyes. Only gently recovery. Animals died between 15 minutes and 8 days after injection. The survivors were without findings after 10 days.
- Gross pathology:
- Animals that died: reddened small intestine in the injection area; one animals with fat tissue necrosis in the abdomen.
Sacrificed animals: Organs essentially without findings.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
