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Diss Factsheets

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from authoritative database

Data source

Reference
Reference Type:
other: Authoritative database
Title:
GESTIS for the CAS: 294-62-2
Author:
IFA GESTIS
Year:
2017
Bibliographic source:
GESTIS SUBSTANCE Database (information system in hazardous substance of the Berufsgenossenscheftn), 2017

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Principles of method if other than guideline:
To assess the ocular irritation potential of Cyclododecane in rabbits as per OECD 405 Guidelines
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Cyclododecane
EC Number:
206-033-9
EC Name:
Cyclododecane
Cas Number:
294-62-2
Molecular formula:
C12H24
IUPAC Name:
Cyclododecane
Test material form:
solid
Details on test material:
Name of the test chemical: Cyclododecane
Molecular Formula: C12H24
Molecular Weight: 168.322 g/mol
InChI: 1S/C12H24/c1-2-4-6-8-10-12-11-9-7-5-3-1/h1-12H2
Substance Type: Organic
Physical State: Solid
Specific details on test material used for the study:
Name of the test chemical: Cyclododecane
Molecular Formula: C12H24
Molecular Weight: 168.322 g/mol
InChI: 1S/C12H24/c1-2-4-6-8-10-12-11-9-7-5-3-1/h1-12H2
Substance Type: Organic
Physical State: Solid

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
no data available

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
no data available
Duration of treatment / exposure:
no data available
Observation period (in vivo):
no data available
Duration of post- treatment incubation (in vitro):
no data available
Number of animals or in vitro replicates:
no data available
Details on study design:
no data available

Results and discussion

In vitro

Other effects / acceptance of results:
no data available

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: no data available
Score:
5
Max. score:
110
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
no irritation observed

Applicant's summary and conclusion

Interpretation of results:
other: not irritating
Conclusions:
The Primary Irritation Index for cyclododecane was 5/110.
Hence, it was considered to be not irritating to rabbit eyes.
Executive summary:

The ocular irritation potential of Cyclododecane was assessed in rabbits. The study was performed as per OECD 405 Guidelines. Cyclododecane was instilled into rabbit eyes and observed for signs of irritation (dose and duration not specified).

The Primary Irritation Index for cyclododecane was 5/110.

Hence, it was considered to be not irritating to rabbit eyes.