Registration Dossier
Registration Dossier
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EC number: 240-299-7 | CAS number: 16143-80-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from Reports of the Scientific Committee on Cosmetology (seventh series)
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Reports of the Scientific Committee on Cosmetology (seventh series)
- Author:
- Commission of the European Communities
- Year:
- 1 988
- Bibliographic source:
- Directorate-General Environment, Consumer Protection and Nuclear Safety- Commission of the European Communities- Brussels Luxembourg, 1988.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Skin irritation study of test chemical Sodium tris(1,2-naphthoquinone 1-oximato-O,O')ferrate(1-) (CAS No: 16143-80-9) was conducted on rabbits to assess its irritation potential.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sodium tris(1,2-naphthoquinone 1-oximato-O,O')ferrate(1-)
- EC Number:
- 240-299-7
- EC Name:
- Sodium tris(1,2-naphthoquinone 1-oximato-O,O')ferrate(1-)
- Cas Number:
- 16143-80-9
- Molecular formula:
- C30H18FeN3O6.Na
- IUPAC Name:
- Sodium tris(1,2-naphthoquinone 1-oximato-O,O')ferrate(1-)
- Test material form:
- solid
- Details on test material:
- - Name of test material : Sodium tris (1, 2-naphthoquinone 1-oximato-O, O’) ferrate (1- )
- Molecular formula : C30H18FeN3O6.Na
- Molecular weight : 595.3222 g/mol
- Smiles notation : [Na+].[Fe+2].[O]\N=C\1/C(=O)C=Cc2ccccc12.[O]\N=C\3/C(=O)C=Cc4ccccc34.[O]\N=C\5/C(=O)C=Cc6ccccc56
- InChl : HWLCXJRHGUPXJZ-ZHJLFMMCSA-K
- Substance type: Organic
- Physical state: Solid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material : Sodium tris (1, 2-naphthoquinone 1-oximato-O, O’) ferrate (1- )
- Molecular formula : C30H18FeN3O6.Na
- Molecular weight : 595.3222 g/mol
- Smiles notation : [Na+].[Fe+2].[O]\N=C\1/C(=O)C=Cc2ccccc12.[O]\N=C\3/C(=O)C=Cc4ccccc34.[O]\N=C\5/C(=O)C=Cc6ccccc56
- InChl : HWLCXJRHGUPXJZ-ZHJLFMMCSA-K
- Substance type: Organic
- Physical state: Solid
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- other: Intact or abraded skin
- Vehicle:
- other: Aqueous Suspension
- Controls:
- not specified
- Amount / concentration applied:
- Amount : 500mg
Concentration applied: 50% - Duration of treatment / exposure:
- No data available
- Observation period:
- No data available
- Number of animals:
- No data available
- Details on study design:
- No data available
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No irritation was observed in treated animals.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not irritating
- Conclusions:
- The test material Sodium tris(1,2-naphthoquinone 1-oximato-O,O')ferrate(1-) (CAS No: 16143-80-9) was considered to be not irritating to the skin of rabbit.
- Executive summary:
The skin irritation study of test chemical Sodium tris(1,2-naphthoquinone 1-oximato-O,O')ferrate(1-) (CAS No: 16143-80-9) was conducted on rabbits to assess its irritation potential.
About 500 mg of 50% aqueous suspension of Sodium tris(1,2-naphthoquinone 1-oximato-O,O')ferrate(1-) was applied on intact or abraded skin of each rabbit and then observed for skin reactions.
None of the treated rabbits showed positive reaction. Hence Sodium tris(1,2-naphthoquinone 1-oximato-O,O')ferrate(1-) (CAS No: 16143-80-9) was considered to be not irritating to the skin of rabbit.
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