Registration Dossier
Registration Dossier
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EC number: 620-459-6 | CAS number: 130841-23-5
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Limit test:
- yes
Test material
- Reference substance name:
- 1,4-dichloro-2-(1,1,2,3,3,3-hexafluoropropoxy)-5-nitrobenzene
- EC Number:
- 620-459-6
- Cas Number:
- 130841-23-5
- Molecular formula:
- C9H3Cl2F6NO3
- IUPAC Name:
- 1,4-dichloro-2-(1,1,2,3,3,3-hexafluoropropoxy)-5-nitrobenzene
Constituent 1
Test animals
- Species:
- rat
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Ciba-Geigy Ltd., Animal Production
- Weight at study initiation: 166 - 211 g
- Housing: segregated by sex, group-housed (5 animals per cage) in Macrolon cages, type 4, with standardize soft wood bedding
- Diet (e.g. ad libitum): yes
- Water (e.g. ad libitum): yes
- Acclimation period: at least 5 days before exposure
ENVIRONMENTAL CONDITIONS
- Temperature (°C): ca. 22 °C
- Humidity (%): ca, 55 %
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose only
- No. of animals per sex per dose:
- 5 per sex
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 5 360 mg/m³ air
- Mortality:
- No Mortalities occured upon exposure to CGA 230672 techn. at a conentration of 5366 mg/m3.
Consenquently, the study was considered a limit test as definded by the OECD test guideline 403. - Clinical signs:
- other: In the animals exposed to the test article piloerection, huched posture, dyspnea, and reduced spontaneous activity were observed to a similar extend. They recovered within 9 days.
- Body weight:
- The mean body weight for the control group and the group exposed to the test article, measured before exposure and on days 7 and 14 for each sex, are shown in Table 3.
The test article exposed females showed a significant lower body weight grain in the second week after exposure.
Applicant's summary and conclusion
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