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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The study is classified as reliable with restriction because although it is a pre-guideline study, it is similar to current guidelines and therefore deemed sufficient to assess the acute toxicity of dodecane-1-thiol.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977

Materials and methods

Principles of method if other than guideline:
In a pre-guideline study, WBS/W rats (10 males) were administered 5000 mg/kg bw of dodecane-1-thiol (undiluted) by stomach tube. The animals were then observed for 14 days following exposure.
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Reference substance name:
Dodecane-1-thiol (CAS # 112-55-0)
IUPAC Name:
Dodecane-1-thiol (CAS # 112-55-0)
Details on test material:
- Name of test material (as cited in study report): n-dodecyl mercaptan (dodecane-1-thiol)

Test animals

Species:
rat
Strain:
other: WBS/W
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 200 g

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
5000 mg/kg
No. of animals per sex per dose:
10
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
>= 5 000 mg/kg bw
Remarks on result:
other: Based on lack of mortality and systemic toxicity effects
Mortality:
No mortality was reported through the study period
Clinical signs:
other: No data reported.
Gross pathology:
No data reported.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information No mortalities were observed at 5000 mg/kg. Criteria used for interpretation of results: EU
Conclusions:
The acute oral LD50 for dodecane-1-thiol is >= 5000 mg/kg bw.
Executive summary:

In an acute toxicity study, male WBS/W rats (10/dose) were orally administered (via gavage) a single dose of 5000 mg/kg of dodecane-1-thiol by gavage. The animals were subsequently observed for a period of 14 days.

 

No mortalities were observed. All animals showed significant daily body weight losses for three to four days, which were recovered by six to eleven days after treatment. Based on the lack of mortality and treatment-related systemic toxicity efffects, the acute oral LD50 for dodecane-1-thiol was higher than 5000 mg/kg bw.

The study received a Klimisch score of 2 and is classified as reliable with restriction because although it is a pre-guideline study, it is similar to current guidelines and therefore deemed sufficient to assess the acute toxicity of dodecane-1-thiol.