Registration Dossier
Registration Dossier
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EC number: 240-457-5 | CAS number: 16409-43-1
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: study with limited documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
- Principles of method if other than guideline:
- Acute dermal toxicity test in rabbits
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- (2S-cis)-tetrahydro-4-methyl-2-(2-methyl-1-propenyl)-2H-pyran
- EC Number:
- 221-217-9
- EC Name:
- (2S-cis)-tetrahydro-4-methyl-2-(2-methyl-1-propenyl)-2H-pyran
- Cas Number:
- 3033-23-6
- Molecular formula:
- C10H18O
- IUPAC Name:
- (2S-cis)-tetrahydro-4-methyl-2-(2-methyl-1-propenyl)-2H-pyran
- Details on test material:
- - Name of test material (as cited in study report): Rose oxide levo
- Other: stereoisomer of rose oxide
- Lot/batch No.: 73-222
no further data given
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- no data
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 3 (sex not specified)
- Control animals:
- other: not applicable
- Details on study design:
- - Duration of observation period following administration: 14 days
no further data given
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality observed
- Clinical signs:
- other: Slight erythema in 2/3 animals Moderate erythema in 1/3 animals Moderate edema in 3/3 animals
- Gross pathology:
- No data
Applicant's summary and conclusion
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