Registration Dossier

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: study with limited documentation

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973
Report Date:
1973

Materials and methods

Principles of method if other than guideline:
Acute dermal toxicity test in rabbits
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Rose oxide levo
- Other: stereoisomer of rose oxide
- Lot/batch No.: 73-222
no further data given

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
no data

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Duration of exposure:
no data
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
3 (sex not specified)
Control animals:
other: not applicable
Details on study design:
- Duration of observation period following administration: 14 days
no further data given

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
No mortality observed
Clinical signs:
Slight erythema in 2/3 animals
Moderate erythema in 1/3 animals
Moderate edema in 3/3 animals
Body weight:
No data
Gross pathology:
No data

Applicant's summary and conclusion