Registration Dossier
Registration Dossier
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EC number: 249-050-7 | CAS number: 28479-22-3
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well documented and scientifically acceptable
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
- Principles of method if other than guideline:
- Method: other: Code of Federal Regulations, Title 16, Section 1500.42; 100 µl substance was applied into the conjunctival sac of the right eye. Reading was carried out 24, 48 and 72 h after start of application.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3-chloro-p-tolyl isocyanate
- EC Number:
- 249-050-7
- EC Name:
- 3-chloro-p-tolyl isocyanate
- Cas Number:
- 28479-22-3
- Molecular formula:
- C8H6ClNO
- IUPAC Name:
- 2-chloro-4-isocyanato-1-methylbenzene
- Details on test material:
- no data
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- up to 8 d
- Observation period (in vivo):
- 24, 48 and 72 h (8 d result not used for assessment)
- Number of animals or in vitro replicates:
- 6
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 h
- Score:
- 44.5
- Max. score:
- 110
- Reversibility:
- not fully reversible within: 8 d
Applicant's summary and conclusion
- Interpretation of results:
- highly irritating
- Remarks:
- Migrated information
- Executive summary:
100 µl substance was applied into the conjunctival sac of the right eye. Reading was carried out 24, 48 and 72 h after start of application. Result: substance is moderately/strong irritant
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