Registration Dossier
Registration Dossier
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EC number: 249-050-7 | CAS number: 28479-22-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well documented and scientifically acceptable
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
- Principles of method if other than guideline:
- single oral application per gavage of 5 ml/kg bw of substance on 5 male and 5 female rats
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 3-chloro-p-tolyl isocyanate
- EC Number:
- 249-050-7
- EC Name:
- 3-chloro-p-tolyl isocyanate
- Cas Number:
- 28479-22-3
- Molecular formula:
- C8H6ClNO
- IUPAC Name:
- 2-chloro-4-isocyanato-1-methylbenzene
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 5.0 ml kg/bw = 6100 mg/kg bw (density ca. 1.229 g/cm³)
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- post observation period: 14 days
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- > 6 100 mg/kg bw
- Mortality:
- one animal died on day 3 after application
- Clinical signs:
- other: temporary fortified diuresis
- Gross pathology:
- no data
Any other information on results incl. tables
no data
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information
- Executive summary:
method: single oral application per gavage of 5 ml/kg bw (ca. 6100 mg/kg bw) of substance on 5 male and 5 female rats
result: LD50 > 5 ml kg/bw (= 6100 mg/kg bw), density of 3-chloro-p-tolylisocyanate ca. 1.229 g/cm³
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