Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 206-386-9 | CAS number: 335-27-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Testing performed in 1967
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 967
- Report date:
- 1967
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- The testing pre-dates OECD, but is broadly similar.
- Deviations:
- yes
- Remarks:
- A single (very high) dose was used.
- GLP compliance:
- no
- Test type:
- fixed dose procedure
Test material
- Reference substance name:
- 1,1,2,2,3,3,4,5,5,6-decafluoro-4,6-bis(trifluoromethyl)cyclohexane
- EC Number:
- 206-386-9
- EC Name:
- 1,1,2,2,3,3,4,5,5,6-decafluoro-4,6-bis(trifluoromethyl)cyclohexane
- Cas Number:
- 335-27-3
- Molecular formula:
- C8F16
- IUPAC Name:
- 1,1,2,2,3,3,4,5,5,6-decafluoro-4,6-bis(trifluoromethyl)cyclohexane
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Neat material
Test animals
- Species:
- rat
- Strain:
- other: C.F.E.
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Weight range 91 g to 128 g, starved for 20 hour prior and 4 hour after.
Administration / exposure
- Route of administration:
- oral: gavage
- Doses:
- A total of 100 ml/kg (183 000 mg/kg) in five doses over six hours.
- No. of animals per sex per dose:
- 5 male, 5 female
- Control animals:
- yes
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 100 mL/kg bw
- Based on:
- test mat.
- Mortality:
- None.
- Clinical signs:
- None specified.
- Body weight:
- No effect.
- Gross pathology:
- "Terminal autopsy failed to reveal any gross effects which could be attributed to treatment with test compounds"
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- "According to Gleason, Gosselin and Hodge (1963), the two compounds may be categorised as "practically non-toxic"."
- Executive summary:
The material is non-toxic.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
