Androsta-1,4-diene-17-carbothioic acid, 6,9-difluoro-11,17-dihydroxy-16-methyl-3-oxo-, (6.alpha.,11.beta.,16.alpha.,17.alpha.)-

Surface tension

Link to relevant study record(s)

Reference

Endpoint:

surface tension

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2015

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.5 (Surface Tension)

Deviations:

no

GLP compliance:

yes

Type of method:

ring method

Surface tension:

ca. 55.7 mN/m

Temp.:

20 °C

Conc.:

9 mg/L

Table 8.1 : Surface tension data

Solution age (minutes)	Surface tension reading (mN/m)
Run 1
0	66.2
30	56.6
60	55.9
120	55.6
180	55.7
240	55.7
300	55.7
360	55.7
Run 2
0	60.2
30	56.8
60	55.7
120	55.7
180	55.7
240	55.7

Conclusions:

Mean surface tension at 20C is 55.7 mN/m.

Executive summary:

1.0 mg of test material was weighed into a 100 ml flask and filled up to 100 ml using HPLC Grad Water. The sample filtered through a 1 µl acrodisc filter and then diluted to 90 %. The surface tension of the material was then measured in accordance to EU Regulation (EC) 440/2008, Annex Part A test A5. The mean surface tension at 20 C was 55.7 mN/m.

Key value for chemical safety assessment

Surface tension:

55.7

in mN/m at 20°C and concentration in mg/L:

9

Additional information

1.0 mg of test material was weighed into a 100 ml flask and filled up to 100 ml using HPLC Grad Water. The sample filtered through a 1 μl acrodisc filter and then diluted to 90 %.