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Boiling point

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Reference
Endpoint:
boiling point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
24 November 2015 to 11 January 2016
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Remarks:
The study was conducted according to an internationally recognized method, and under GLP. Restrictions apply considering the difficulty of interpreting the results obtained by DSC for such complex substance and the approximation related to the initial enthalpy changes. Test substance is adequately specified. Therefore validation with restrictions applies.
Qualifier:
according to
Guideline:
OECD Guideline 103 (Boiling Point)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.2 (Boiling Temperature)
Deviations:
no
Principles of method if other than guideline:
Not applicable
GLP compliance:
yes (incl. certificate)
Remarks:
UK GLP compliance programme (inspected on 17 June 2015 / signed on 24 September 2015)
Type of method:
differential scanning calorimetry
Key result
Boiling pt.:
>= 180 - <= 400 °C
Atm. press.:
>= 97.9 - <= 99.4 kPa

The test item has been determined to partially boil over the range approximately 180 to 400 °C (453 to 673 K) at 97.9 to 99.4 kPa.

Only 0 to 10% of weight loss were observed in the two latest tests while 54% to 67% of weight loss were observed in the four first determinations.

(Loss on heating: 67, 63, 67, 54, 10 and 0 % in determinations 1, 2, 3, 4, 5 and 6, respectively).

Atmospheric pressure: Determinations 1 & 2: 98.3 kPa ; Determinations 3 & 4: 99.4 kPa; Determinations 5 & 6: 97.9 kPa

Executive summary:

The boiling point of the test substance was measured under GLP according to OECD 103 / EU A2 guideline, using the differential scanning calorimetry method.

Two tests were performed under air between 20 and 400°C at 20°C/min and two tests were conducted under nitrogen in the same conditions. Then two tests were performed under air between 20 and 180°C at 10°C/min.

The test item has been determined to partially boil over the range approximately 180 to 400 °C (453 to 673 K) at 97.9 to 99.4 kPa.

The appearance of the sample (residue) and the weight loss were recorded after the test.

Considering the weight loss during the tests and the endothermic effect observed during the DSC test, we can conclude that the test item partially boils within a range of temperature. However the study only led to approximate a range of temperature due to the low rate of enthalpy changes during boiling.

Decomposition of the substance cannot be considered based on the observations reported in the report.

Description of key information

The test item has been determined to partially boil over the range approximately 180 to 400 °C (453 to 673 K) at 97.9 to 99.4 kPa.

Key value for chemical safety assessment

Additional information

A reliable experimental study, conducted according to a recognized OECD/EC, DSC method and under GLP, is available. It is considered as a key study. As the result is expressed as a range, it cannot be retained as key value.

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