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Description of key information

Skin and Eye irritation was estimated by using Toxtree decision rule system and Derek Nexus.

Skin irritation

Derek Nexus identified no alerts for the target compound; Reliability assessment not applicable.

Toxtree identified one exclusion rule “compounds with melting point greater than 200°C (4-Chlorobenzenesulfonic acid experimental melting point range = 67 -102 °C)”. The exclusion rule is not satisfied and the prediction is unknown.


Eye irritation

Derek Nexus identified no alerts for the target compound.

Toxtree predicted that 4-Chlorobenzenesulfonic acid can cause serious lesions to the eye. An assessment of the reliability of the prediction is not provided.

It was concluded that 4-Chlorobenzenesulfonic acid can cause serious lesions to the eye.

Key value for chemical safety assessment

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irreversible damage)

Additional information

Justification for classification or non-classification

The eye irritation potential of the target compound was predicted employing two tools. Based on the Toxtree and Derek Nexus predictions, it was concluded that 4-Chlorobenzenesulfonic acid can cause serious lesions to the eye. therefore

4-chlorobenzensolfonic acid is classified as Eye Damage 1, H318 according to CLP Regulation.

The skin irritation potential of the target compound was predicted employing two tools. The Toxtree prediction was unknown and the Derek Nexus prediction gives not Reliability assessment.

4-chlorobenzensolfonic acid is a strong acid (pKa for arensulfonic acids < 1.75).
Taking into account its acid strength, it is expected to become corrosive when moistened or in contact with moist skin or mucous membranes.Therefore 4-chlorobenzensolfonic acid is classified as Skin Corr. 1A, H314 according to CLP Regulation.

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