Registration Dossier
Registration Dossier
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EC number: 629-754-4 | CAS number: 210988-99-1
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Genetic toxicity in vivo
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Ames Test
In a GLP-compliant Ames Test following OEDCD guideline 471, the test substance was tested for its mutagenic potential based on the ability to induce point mutations in selected loci of bacterial strains Salmonella typhimurium TA 1535, TA 100, TA 1537, TA 98 and E. coli WP2 uvrA. The dose range used was 0.1 μg - 5000 μg/plate in the standard plate test and 0.1 μg - 33 μg/plate in the preincubation test. Both tests were performed with and without metabolic activation (liver S9 mix from induced rats). Precipitation of the test substance was found at 5 000 μg/plate with and without S9 mix. A strong bacteriotoxic effect was observed depending on the strain and test conditions from about 1.0 μg/plate onward. A relevant increase in the number of his+ or trp+ revertants was not observed in the standard plate test or in the preincubation test either without S9 mix or after the addition of a metabolizing system. Thus, under the experimental conditions of this study, the test substance is not mutagenic in the Salmonella typhimurium/Escherichia coli reverse mutation assay in the absence and the presence of metabolic activation.
Justification for classification or non-classification
Classification, Labeling, and Packaging Regulation (EC) No. 1272/2008
The available experimental test data are reliable and suitable for the purpose of classification under Regulation (EC) No.1272/2008. Based on the data, classification for acute toxicity is not warranted under Regulation (EC) No.1272/2008.
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