Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
Reaction mass of:pentasodium 7-amino-3-((E)-(4-((Z)-(4-(4-((E)-(4-((E)-(6-amino-1-hydroxy-3-sulfonatonaphthalen-2-yl)diazenyl)-7-sulfonato-5,8-dihydronaphthalen-1-yl)diazenyl)-2-sulfonatophenylamino)phenyl)diazenyl)-6-sulfonatonaphthalen-1-yl)diazenyl)-4-hydroxynaphthalene-2-sulfonate andpentasodium 7-amino-8-((E)-(4-((Z)-(4-(4-((E)-(4-((E)-(2-amino-5-hydroxy-7-sulfonatonaphthalen-1-yl)diazenyl)-7-sulfonato-5,8-dihydronaphthalen-1-yl)diazenyl)-2-sulfonatophenylamino)phenyl)diazenyl)-6-sulfonatonaphthalen-1-yl)diazenyl)-4-hydroxynaphthalene-2-sulfonate andpentasodium 7-amino-3-((E)-(4-((Z)-(4-(4-((E)-(4-((E)-(2-amino-5-hydroxy-7-sulfonatonaphthalen-1-yl)diazenyl)-7-sulfonato-5,8-dihydronaphthalen-1-yl)diazenyl)-2-sulfonatophenylamino)phenyl)diazenyl)-6-sulfonatonaphthalen-1-yl)diazenyl)-4-hydroxynaphthalene-2-sulfonate
EC number: 940-364-6 | CAS number: -
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- other: read across from analogue substance
- Adequacy of study:
- weight of evidence
- Study period:
- 1993
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
- Principles of method if other than guideline:
- Pre-incubation test. Screening program: strain TA98 placed in standard plates. Evaluation without metabolic activation.
- GLP compliance:
- no
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Trisodium 6-[(2,4-diaminophenyl)azo]-3-[[4-[[4-[[7-[(2,4-diaminophenyl)azo]-1-hydroxy-3-sulphonato-2-naphthyl]azo]phenyl]amino]-3-sulphonatophenyl]azo]-4-hydroxynaphthalene-2-sulphonate
- EC Number:
- 229-326-3
- EC Name:
- Trisodium 6-[(2,4-diaminophenyl)azo]-3-[[4-[[4-[[7-[(2,4-diaminophenyl)azo]-1-hydroxy-3-sulphonato-2-naphthyl]azo]phenyl]amino]-3-sulphonatophenyl]azo]-4-hydroxynaphthalene-2-sulphonate
- Cas Number:
- 6473-13-8
- Molecular formula:
- C44H32N13O11S3Na3
- IUPAC Name:
- trisodium 6-[(2,4-diaminophenyl)azo]-3-[[4-[[4-[[7-[(2,4-diaminophenyl)azo]-1 hydroxy-3-sulphonato-2-naphthyl]azo]phenyl]amino]-3-sulphonatophenyl]azo]-4-hydroxynaphthalene-2-sulphonate
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 98
- Metabolic activation:
- without
- Metabolic activation system:
- No
- Test concentrations with justification for top dose:
- Range 20-5000 µg/plates: 20, 100, 500, 2500, 5000 µg/plate
Controls
- Untreated negative controls:
- yes
- Remarks:
- DMSO
- Positive controls:
- yes
- Remarks:
- NPD
Results and discussion
Test results
- Species / strain:
- S. typhimurium TA 98
- Metabolic activation:
- without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Additional information on results:
- TEST-SPECIFIC CONFOUNDING FACTORS
- Precipitation: 2500-5000 µg/plate
Any other information on results incl. tables
| Revertant/plate | Quotient | |||
| Dose µg/plate | - S9 | M | DS | -S9 |
| Negative control | 29 29 18 |
25 | 6 | 1.0 |
| 20 | 19 13 24 |
19 | 6 | 0.7 |
| 100 | 26 26 26 |
26 | 0 | 1.0 |
| 500 | 31 29 28 |
29 | 2 | 1.2 |
| 2500 | 31 30 24 |
28 | 4 | 1.1 |
| 5000 | 32 31 33 |
32 | 1 | 1.3 |
| Positive control | 608 572 666 |
615 | 47 | 24.3 |
Applicant's summary and conclusion
- Conclusions:
- Negative
Non mutagen; no increase of revertants has been observed. - Executive summary:
Non mutagen; no increase of revertants has been observed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
