Registration Dossier
Registration Dossier
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EC number: 612-182-4 | CAS number: 6161-65-5
Endpoint summary
Administrative data
Description of key information
In a BASF study on eye irritaion/corrition according to OECD 405, the test substance BAS 560 F - (Benzoe-Säure) was found to cause irreversible damage to the eyes of rabbits.
An in vitro assay on skin corrosion (EpiDerm), according to OECD 431, no indications of severe skin damage were noticed. However, this result does not yet allow for evaluatio of skin irritation.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
The potential of the test substance to induce irreversible damage to the eyes is clearly outlined by the in vivo eye irritation assay in rabbits, according to OECD 405. Therefore, classification R41 and skin irrit. Cat. 1 is warranted, according to Directive 67/548/EEC and Regulation (EU) No. 1272/2008, respectively.
The available in vitro assay on skin corrosion did not reveal indications of such effects. However, no additional test (i.e. OECD 439) has been conducted to investigate the skin irritation potential of the compound. In an LLNA Assay, skin irritation was observed at concentrations of 30% of the test substance dissolved in acetone. Takeing into account the potential to cause irreversible damage to the eyes and addressing the data gap on skin irritaion, the test substance warrants a worst-case-classification as skin irrit. Cat 2 and R38, according Regulation (EU) No. 1272/2008 and Directive 67/548/EEC, respectively.
Effects on skin irritation/corrosion: irritating
Effects on eye irritation: corrosive
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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