Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Handbook data are considered to be from a trusted source

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
Registry of Toxic Effects of Chemical Substances
Author:
R.J. Lewis, R.L. Tatken
Year:
1979
Bibliographic source:
U.S. Dept. Health and Human Services, NIOSH
Reference Type:
review article or handbook
Title:
OECD SIDS "Vinyl Chloride"
Author:
American Chemistry Council, Wendy Sherman
Year:
2001
Bibliographic source:
UNEP Publications, Bern, p. 3 - ECOSAR

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
GLP compliance:
not specified
Test type:
fixed dose procedure

Test material

Constituent 1
Chemical structure
Reference substance name:
Chloroethylene
EC Number:
200-831-0
EC Name:
Chloroethylene
Cas Number:
75-01-4
Molecular formula:
C2H3Cl
IUPAC Name:
chloroethene

Test animals

Species:
rat
Strain:
Lewis
Sex:
male/female

Results and discussion

Effect levelsopen allclose all
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 500 mg/kg bw
Based on:
test mat.
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 4 000 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion