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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 03 January 2012- 19 March 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study has been performed according to OECD and EC guidelines and according to the principles of GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Version / remarks:
- (2008)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- (2004)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Details on test material:
- - Physical state: Clear colourless/slightly yellow, sticky resin
- Stability under test conditions: Stable
- Storage condition of test material: At room temperature protected from light
-Stability at higher temperatures: Maximum 1 month at 50°C
- General information: Avoid heat, direct sunlight, acid and base
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficientopen allclose all
- Type:
- log Pow
- Partition coefficient:
- 1.4
- Temp.:
- 35 °C
- Remarks on result:
- other: Not buffered. Peak 3 (area of 49%).
- Type:
- log Pow
- Partition coefficient:
- 3.9
- Temp.:
- 35 °C
- Remarks on result:
- other: Not buffered. Peak 7 (area of 30%).
- Type:
- log Pow
- Partition coefficient:
- <= 0.3
- Temp.:
- 35 °C
- Remarks on result:
- other: Not buffered. Peak 1 (area 0.90%)
- Type:
- log Pow
- Partition coefficient:
- >= 0.6 - 6.2
- Temp.:
- 35 °C
- Remarks on result:
- other: Not buffered. Peaks 2 to 13 (included), without peaks 1, 3 and 7. Peak areas ranging from 0.55% to 5.9% (included).
- Details on results:
- In the HPLC chromatogram of the test solution, 13 different peaks were observed. Individual results: see table below. The equation of the regression line was: log k` = 0.305 x log Pow – 0.707 (r = 0.98; n=12). Chromatograms and regression line: see attachment.
Any other information on results incl. tables
Table: Powof the test substance
Substance |
tr,1 |
tr,2 |
mean tr |
log Pow |
Pow |
Area |
|
|
|
|
|
|
|
Formamide (t0) |
1.141 |
1.136 |
1.139 |
|
|
|
|
|
|
|
|
|
|
Ethylmethylketone |
1.352 |
1.351 |
|
0.3 |
|
|
Toluene |
3.029 |
3.020 |
|
2.7 |
|
|
1,4-Dichlorobenzene |
3.919 |
3.905 |
|
3.4 |
|
|
Dibenzyl |
7.878 |
7.813 |
|
4.8 |
|
|
Fluoranthene |
10.930 |
10.799 |
|
5.1 |
|
|
4,4’-DDT |
16.807 |
16.645 |
|
6.5 |
|
|
|
|
|
|
|
|
|
NS203602 Peak1 |
1.398 |
1.397 |
1.398 |
<0.3 |
<2.0 |
0.90 |
NS203602 Peak2 |
1.483 |
1.483 |
1.483 |
0.6 |
4.1 |
2.0 |
NS203602 Peak3 |
1.723 |
1.724 |
1.724 |
1.4 |
2.3 x 101 |
49 |
NS203602 Peak4 |
2.310 |
2.316 |
2.313 |
2.4 |
2.3 x 102 |
2.3 |
NS203602 Peak5 |
3.017 |
3.022 |
3.020 |
3.0 |
1.1 x 103 |
1.8 |
NS203602 Peak6 |
3.461 |
3.482 |
3.472 |
3.3 |
2.2 x 103 |
0.83 |
NS203602 Peak7 |
4.710 |
4.740 |
4.725 |
3.9 |
8.9 x 103 |
30 |
NS203602 Peak8 |
5.450 |
5.474 |
5.462 |
4.2 |
1.6 x 104 |
0.71 |
NS203602 Peak9 |
6.110 |
6.146 |
6.128 |
4.4 |
2.6 x 104 |
0.55 |
NS203602 Peak10 |
7.341 |
7.387 |
7.364 |
4.7 |
5.4 x 104 |
5.2 |
NS203602 Peak11 |
11.179 |
11.201 |
11.190 |
5.4 |
2.6 x 105 |
0.67 |
NS203602 Peak12 |
11.529 |
11.742 |
11.636 |
5.5 |
3.0 x 105 |
0.70 |
NS203602 Peak13 |
18.531 |
18.525 |
18.528 |
6.2 |
1.6 x 106 |
5.9 |
|
|
|
|
|
|
|
Applicant's summary and conclusion
- Conclusions:
- The log Pow of the test substance components ranges from ≤ 0.3 to 6.2 (13 peaks in total).
Log Pow values for the two major peaks (49% and 30% peak area) were 1.4 and 3.9, respectively.
Log Pow values for two other large peaks (5.2% and 5.9% peak area) were 4.7 and 6.2 respectively.
The log Pow values for the 9 smaller peaks (areas from0.55 to 2.3%) ranges from ≤ 0.3 to 5.5.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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