Registration Dossier
Registration Dossier
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EC number: 251-752-3 | CAS number: 33941-99-0
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 04-Nov-2015 to 02-Dec-2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Staatliches Gewerbeaufsichtsamt Hildeshelm
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Key result
- Type:
- log Pow
- Partition coefficient:
- 2.19
- Temp.:
- 24.7 °C
- Remarks on result:
- other: Temperature of HPLC column. No pH value provided.
- Conclusions:
- A log Pow of 2.19 (at 24.7 °C) was determined for the test substance according to EU Method A.8.
Reference
Results of Test Item Analysis
The table contains the retention time data and calculated log k values of the test item. Two individual log Pow values were derived under consideration of the first and second calibration. Finally, a mean value was calculated from these individual log Pow values.
Retention Times, Capacity Factors and Partition Coefficients
tR(min) |
k |
log k |
log Pow |
|
|
1st calibration |
2nd calibration |
||||
5.375 |
8.41 |
0.925 |
2.19 +/- 0.05 2.05 to 2.32 (95 % CI) |
2.18 +/- 0.05 2.05 to 2.31 (95 % CI) |
|
5.377 |
8.42 |
0.925 |
|||
Mean |
5.376 |
8.42 |
0.925 |
2.19 |
|
tR: Retention time
k: Capacity factor test item
Pow : Partition Coefficient (n-octanol / water)
CI : Confidence Interval
Conclusions
Two individual log Kow values for the test item were derived under consideration of the first and second calibration. Finally, a mean value was calculated from these individual log Pow values to be 2.19.
Description of key information
Log Pow: 2.19 at 24.7 °C (EU Method A.8., HPLC method)
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 2.19
- at the temperature of:
- 24.7 °C
Additional information
A log Pow of 2.19 (at 24.7 °C) was determined for the test substance according to EU Method A.8.
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