Registration Dossier
Registration Dossier
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Reaction mass of Potassium sodium 3-{[4-({3-(substitutedamino)-4-[(2-sulfonato-4-{[2-(sulfonatooxy)ethyl]sulfonyl}phenyl)diazenyl]phenyl}amino)-6-chloro-heteromonocyl-2-yl]amino}-2-substituted-5-{[2-(sulfonatooxy)ethyl]sulfonyl}benzenesulfonate (1:3:1) and Potassium sodium 3-[(4-{[3-(subsitutedamino)-4-{[4-(ethenylsulfonyl)-2-sulfonatophenyl]diazenyl}phenyl]amino}-6-chloro-heteromonocy-2-yl)amino]-2-substituted-5-{[2-(sulfonatooxy)ethyl]sulfonyl}benzenesulfonate (3:9:3)
EC number: - | CAS number: -
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
This study was performed to assess the chronic toxicity of FAT 40863/A TE to the freshwater invertebrate Daphnia magna.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
This study was performed to assess the chronic toxicity of the test item to the freshwater invertebrateDaphnia magna. The method followed was designed to be compatible with the OECD Guidelines for Testing of Chemicals (2012) No 211, "Daphnia magnaReproduction Test" referenced as Method C.20 of Commission Regulation (EC) No. 440/2008 and the US EPA Draft Ecological Effects Test Guidelines OCSPP 850.1300 "Daphnid Chronic Toxicity Test". The test was conducted following a semi-static design with test solutions renewed three times per week.
Methods:
Based on the results of an acute toxicity test (Harlan Study Number: 41304704),Daphnia magnawere exposed (10 replicates of a single daphnid per group) to an aqueous solution of the test item over a range of nominal test concentrations of 1.0, 3.2, 10, 32 and 100 mg/L for a period of 21 days. The test solutions were renewed 3 times per week.
The numbers of live and dead adult Daphnia and young daphnids (live and dead) were determined daily. The Daphnia were fed daily with a mixture of algal suspension and Tetramin®flake food suspension.
Results:
Analysis of the freshly prepared 100 mg/L test preparations on Days 0, 5, 12 and 19 and of the old or expired test preparations on Days 3, 7, 14 and 21 showed measured test concentrations to range from 102% to 106% of nominal value and so the results are based on nominal test concentrations only.
Exposure ofDaphnia magnato the test item gave the following results based on the nominal test concentrations:
Endpoint |
Concentration (mg/L) |
|
Adult growth |
EC10 |
>100 |
|
EC50 |
>100 |
No Observed Effect Concentration (NOEC) |
100 |
|
Lowest Observed Effect Concentration (LOEC) |
>100 |
|
Endpoint |
Concentration (mg/L) |
|
Reproduction⃰ |
EC10 |
>100 |
|
EC50 |
>100 |
No Observed Effect Concentration (NOEC) |
100 |
|
Lowest Observed Effect Concentration (LOEC) |
>100 |
|
Maximum Acceptable Toxicant Concentration (MATC)*1 |
100 |
⃰Result calculated from total neonates produced
*1Result calculated from lowest calculated NOEC and LOEC
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