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Diss Factsheets

Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from publication.

Data source

Reference
Reference Type:
publication
Title:
CONTACT ECZEMA CAUSED BY TRUE TEAK (Tectona grandis)
Author:
H. K. KROGH
Year:
1964
Bibliographic source:
BRITISH JOURNAL OF INDUSTRIAL MEDICINE, 1964, 21, 65

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: As mention below
Principles of method if other than guideline:
Patch test wawsperfromed to evaluate the sensitization potential of the test chemical among workers working in a furniture factory
GLP compliance:
not specified
Type of study:
patch test
Justification for non-LLNA method:
Not specified.

Test material

Constituent 1
Chemical structure
Reference substance name:
2-methylanthraquinone
EC Number:
201-539-6
EC Name:
2-methylanthraquinone
Cas Number:
84-54-8
Molecular formula:
C15H10O2
IUPAC Name:
2-methyl-9,10-dihydroanthracene-9,10-dione
Test material form:
solid: particulate/powder
Details on test material:
IUPAC name : 2-methyl-9,10-anthraquinone
Molecular formula : C15H10O2
Molecular weight : 222.242 g/mol
Substance type: Organic
Physical property: Orange powder
InChI: 1S/C15H10O2/c1-9-6-7-12-13(8-9)15(17)11-5-3-2-4-10(11)14(12)16/h2-8H,1H3
Smiles: c12c(C(c3ccccc3C1=O)=O)ccc(c2)C

In vivo test system

Test animals

Species:
other: Human
Strain:
other:
Remarks:
Not applicable
Sex:
not specified
Details on test animals and environmental conditions:
Details on test animal
TEST ANIMALS
72 furniture factory workers were investigated with the history of allergic contact eczema caused by true teak (Tectona grandis). All the 72 workers were interviewed and examined for skin lesions.

Study design: in vivo (non-LLNA)

Induction
Route:
epicutaneous, occlusive
Vehicle:
not specified
Concentration / amount:
Native teak dust was applied which contain unknown concentration of 2-methyl-9,10-anthraquinone.
Day(s)/duration:
24 hour
Adequacy of induction:
not specified
Challenge
No.:
#1
Route:
epicutaneous, occlusive
Vehicle:
other: Acetone
Concentration / amount:
0.1,0.5, 1 and 2%
Day(s)/duration:
24 hour
Adequacy of challenge:
not specified
No. of animals per dose:
72 Human volunteers
Details on study design:
Details on study design

MAIN STUDY

A. INDUCTION EXPOSURE
- No. of exposures: single
1- Exposure period: 24 hour
- Test groups: 72
- Control group:10
- Site: The patch was applied on the volar side of the left forearm.
- Frequency of applications: No data available.
- Duration: 24 hour
- Concentrations: native teak dust was applied which contain unknown concentration of the test chemical

B. CHALLENGE EXPOSURE
- No. of exposures:4
- Day(s) of challenge: No data available.
- Exposure period: 24 hour
- Test groups:72
- Control group:10
- Site: The patch was applied on the volar side of the left forearm.
- Concentrations: 0.1,0.5, 1 and 2%
- Evaluation (hr after challenge):24 ,48 and 72 hour


Other:The interpretation of the patch testswas based on the usual criteria and was recorded as allergic, toxic, or negative.
Challenge controls:
Yes, 10 challenge controls were investigated
Positive control substance(s):
not specified

Results and discussion

Positive control results:
No data available.

In vivo (non-LLNA)

Resultsopen allclose all
Key result
Reading:
1st reading
Hours after challenge:
24
Group:
test chemical
Dose level:
0.1,0.5, 1 and 2%
No. with + reactions:
0
Total no. in group:
72
Clinical observations:
No skin sensitization effect were observed.
Remarks on result:
no indication of skin sensitisation
Key result
Reading:
1st reading
Hours after challenge:
48
Group:
test chemical
Dose level:
0.1,0.5, 1 and 2%
No. with + reactions:
0
Total no. in group:
72
Clinical observations:
No skin sensitization effect were observed.
Remarks on result:
no indication of skin sensitisation
Key result
Reading:
1st reading
Hours after challenge:
72
Group:
test chemical
Dose level:
0.1,0.5, 1 and 2%
No. with + reactions:
0
Total no. in group:
72
Clinical observations:
No skin sensitization effect were observed.
Remarks on result:
no indication of skin sensitisation

Applicant's summary and conclusion

Interpretation of results:
other: not sensitizing
Conclusions:
No skin sensitization effects were observed in test group or control group. Therefore, the test chemical was considered to be not sensitizing to human skin.
Executive summary:

Patch test was performed to evaluate the sensitization potential of the test chemical among workers working in a furniture factory

A group of 72 furniture factory workers were investigated with the history of allergic contact eczema caused by true teak (Tectona grandis). All the 72 workers were interviewed and examined for skin lesions. For this purpose a Patch test was performed with native teak dust. The patch were applied for 24 hours on the volar side of the left forearm and read at the end of this period and read again after 48 and 72 hours. A challenge exposure was performed on the workers who showed allergic reactions. The patch was applied at the concentration of 0.1, 0.5, 1 and 2% test chemical. Acetone was used as vehicle.The interpretation of the patch tests was based on the usual criteria and was recorded as allergic, toxic, or negative.Identical Patch tests were applied on 10 controls. No skin sensitization effects were observed in test group or control group. Therefore, the test chemical was considered to be not sensitizing to human skin.