4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonamide

Guidance on Safe Use

First-aid measures

Emergency measure - Inhalation: Remove to fresh air, monitor blood pressure, respiration,

temperature and general condition.  Get medical attention

promptly.

Emergency measure - Eyes: Immediately flush eyes with large amounts of water for 15

minutes.  Get prompt medical attention.

Emergency measure - Skin: Remove contaminated clothing.  Wash skin with soap and

water.  Get medical attention if irritation develops.

Emergency measure - Ingestion: Provide general support and monitor blood pressure,

respiration, temperature and general condition.  Get medical

attention promptly.

Fire-fighting measures

Recommended extinguishing agent: Use dry chemical, carbon dioxide, water spray, regular foam

or extinguishing agent suitable for surrounding fire.

Product arising from burning: Oxides of nitrogen and sulfur.

Not highly flammable. High sensitivity of a dust cloud to ignition, based on minimum ignition

energy. Fine particles (such as dust and mists) may fuel fires/explosions

Protective equipment: Fire fighters should wear pressure demand self-contained

breathing apparatus and full protective gear.

Accidental release measures

Personal Precautions, Protective Equipment and Emergency Procedures

Personnel involved in clean-up should wear appropriate personal protective equipment (see Section 8). Minimize exposure.

Environmental Precautions

Place waste in an appropriately labeled, sealed container for disposal. Care should be taken to avoid environmental release

Measures for Cleaning / Collecting: Contain the source of the spill if it is safe to do so. Collect spilled material by a method that

controls dust generation. Avoid use of a filtered vacuum to clean spills of dry solids, due to the potential for electrostatic discharge and high sensitivity to ignition. Clean spill area thoroughly.

Additional Consideration for Large Spills:

Non-essential personnel should be evacuated from affected area. Report emergency situations immediately. Clean up operations should only be undertaken by trained personnel.

Handling and storage

Precautions for Safe Handling

Avoid open handling. Minimize dust generation. Use local exhaust ventilation or perform work under fume hood/fume cupboard.

This material should not be flowed through nonconductive ducts or pipes because of the potential for electrostatic discharge

ignition. All conductive elements of the system that contact the dry substance should be properly bonded and grounded and

equipped with proper explosion relief or suppression systems. Restricting the use of high resistivity materials, such as plastics,

should be considered. Avoid inhalation and contact with skin, eye, and clothing. When handling, use appropriate personal

protective equipment.. Wash hands and any exposed skin after removal of PPE. Releases to the environment

should be avoided.  Review and implement appropriate technical and procedural waste water and waste disposal measures to prevent occupational exposure

or environmental releases. Potential points of process emissions of this material to the atmosphere should be controlled with

dust collectors, HEPA filtration systems or other equivalent controls.

Storage Conditions: Store at room temperature in properly labeled containers. Keep away from heat, sparks and flames.

Transport information

Land transport (UN RTDG/ADR/RID)

UN number:

UN 3077

Shipping information

Proper shipping name and description:

Environmentally Hazardous Substance, Solid, n.o.s (Valdecoxib)

Chemical name:

Valdecoxib

Language:

English

SpecialProvisions

Inland waterway transport (UN RTDG/ADN(R))

UN number:

3077

Shipping information

Proper shipping name and description:

Environmentally Hazardous Substance, Solid, n.o.s (Valdecoxib)

Chemical name:

Valdecoxib

Language:

English

Remarks

Marine transport (UN RTDG/IMDG)

UN number:

3077

Shipping information

Proper shipping name and description:

Environmentally Hazardous Substance, Solid, n.o.s (Valdecoxib)

Chemical name:

Valdecoxib

Remarks

Air transport (UN RTDG/ICAO/IATA)

UN number:

3077

Shipping information

Proper shipping name and description:

Environmentally Hazardous Substance, Solid, n.o.s (Valdecoxib)

Chemical name:

Valdecoxib

Remarks

SpecialProvisions

Exposure controls / personal protection

Engineering controls should be used as the primary means to control exposures. Use process containment, local exhaust ventilation, or other engineering controls to maintain airborne levels below recommended exposure limits.

Personal Protective Equipment:

Refer to applicable national standards and regulations in the selection and use of personal protective equipment (PPE).

Hands: Wear impervious gloves as minimum protection.

Eyes: Wear safety glasses as minimum protection.

Skin: Wear impervious protective clothing when handling this compound.

Respiratory protection: If the applicable Occupational Exposure Limit (OEL) is exceeded, wear an appropriate respirator with a protection factor sufficient to control exposures to below the OEL.

Stability and reactivity

Danger other than fire: Not known.

Chemical reaction with water: Not known.

Dust explosion: The test substance is an organic powder, therefore, care

should be taken to avoid possible sources of ignition.  The

test substance is not highly flammable, but will burn in a

fire.

Dust explosion determined by test: N

Disposal considerations

Dispose of waste in accordance with all applicable laws and regulations. Member State

specific and Community specific provisions must be considered. Considering the relevant

known environmental and human health hazards of the material, review and implement

appropriate technical and procedural waste water and waste disposal measures to prevent

occupational exposure and environmental release. It is recommended that waste minimization

be practiced. The best available technology should be utilized to prevent environmental

releases. This may include destructive techniques for waste and wastewater.