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Physical & Chemical properties

Water solubility

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Administrative data

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
May 04, 2015
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
GLP compliance:
no
Type of method:
flask method
Water solubility:
ca. 6 580 mg/L
Temp.:
20 °C
pH:
ca. 7.68
Remarks on result:
other: Standard deviation ± 0.48, Average solubility 24-48 hours

PRELIMINARY SOLUBILITY RESULT

Reference samples and extract were first measured in the range 190 / 800 nm, so as to choose the right wavelength for quantitative measurements.

Since absorbance of the test solution kept the same proportions along the UV and visible spectra, preliminary test result was considered for the final result calculations. Wavelength chosen was 254.00 nm.

TEST RESULTS

Reference solutions were measured in the spectrophotometer in quantitative mode, thus generating a calibration curve. Calibration curve was smooth and linear at every concentration. Considering that preliminary test resulted in an absorbance keeping the same shape like the references, its value was considered for the 24 hours’ measurement (test 1). Adjusting concentrations in proportion to the real weights the following results were obtained:

Final test (24 hs): 6.97 g/l

Final test (48 hs): 6.04 g/l

Average solubility: 6.73 g/l

Standard deviation: 0.48

pH satured solution: 7.68

Conclusions:
Average solubility: 6580 mg/l at 20 °C and pH 7.68
Executive summary:

Method

Solubility was performed following the recommendations of the OECD method 105.

Result

Average solubility: 6580 mg/l at 20 °C and pH 7.68

Standard deviation: 0.48

Description of key information

6580 mg/l at 20 °C and pH 7.68

Key value for chemical safety assessment

Water solubility:
6.58 g/L
at the temperature of:
20 °C

Additional information

Shake Flask method - OECD 105