Registration Dossier
Registration Dossier
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EC number: 420-660-7 | CAS number: 74135-10-7 NATRIUM-SUCROSEOCTASULFAT
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 13.02.1996 - 24.02.1996
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Deviations:
- yes
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 404
- GLP compliance:
- yes
- Limit test:
- yes
Test material
- Reference substance name:
- Natrium-Sucroseoctasulfat
- IUPAC Name:
- Natrium-Sucroseoctasulfat
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: Keine (none)
- Duration of exposure:
- 4h
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- other: Signs of toxicity related to dose levels: In 4/5 weiblichen Tieren reduzierte Gewichtszunahme in der ersten Woche p.a. (bei 2 Tieren) bzw. während der ges. Beobachtungszeit (bei 2 Tieren). "ENGLISH" In 4 of 5 females reduced body weight gain
- Other findings:
- Signs of toxicity (local):
Sehr leichte bis ausgeprägte Erytheme in allen Tieren bis
4 Tage p.a.
"ENGLISH"
Very slight to significant erythems in aqll animals up to
day 4 p.a..
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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