Registration Dossier
Registration Dossier
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EC number: 231-970-5 | CAS number: 7782-91-4
Endpoint summary
Administrative data
Description of key information
Not considered to be a skin sensitiser, based on the clear absence of sensitising properties of several molybdenum substances in reliable guinea pig maximisation studies.
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Reliable, guideline conform skin sensitisation studies (guinea pig maximisation tests) are available for four molybdenum substances: sodium molybdate, ammonium dimolybdate, molybdenum trioxide and roasted molybdenite concentrate, all showing a clear absence of sensitising properties to the skin. The four tested substances cover the range of moderately to very soluble substances. Given that (i) all molybdenum substances have been shown to release molybdate as the only relevant molybdenum species upon contact with aqueous media, and (ii) since uptake into/through skin requires dissolution, these four substances are considered to represent worst case surrogates for all other molybdenum substances, so that unrestricted read-across is considered feasible to all other molybdenum substances, including molybdic acid.
Justification for classification or non-classification
Molybdic acid is not expected to show signs of dermal sensitisation, since a range of moderately to very soluble molybdenum substances did not show any skin sensitisation potential in experimental testing.
Thus, molybdic acid is not to be classified according to regulation (EC) 1272/2008 as skin sensitising. Furthermore, molybdic acid has not to be classified according to Directive 67/548/EC as skin sensitising.
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