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EC number: 943-299-1 | CAS number: -
The sensitization rate of CR SB32N2 was 0% and CR SB32N2 caused weak sensitization in guinea pigs (OECD TG406).
Group #1: Control group
Group #2: Treated group
Table 1. Individual Body Weightand Clinical Observations
Body Weight (g)
*On Day 1 and Day 21, pink colored skin or urine were observed in some treated animals.
Table 2. Individual Skin Reaction on Induction Sites
Maximum score (Erythema / Edema)
0 / 1
2 / 2
4 / 3
4 / 4
4 / 2
0 / 0
3 / 2
2 / 3
3 / 3
1 / 2
2 / 1
3 / 1
2 / 0
4 / 4
-: no observation was conducted
Table 3. Individual Sensitization Observation
This test using the procedures outlined in the QPS Taiwan Study Plan for T65316014-IR which is based on the SOP for the OECD 406 (CTPS-TE00516) and OECD 406 (OECD, 1992). The results of this OECD 406 test for CR SB32N2 show that test reliability criteria was met.
A 10% and 50% CR SB32N2 was used for intradermal injection and occlusively patched, respectively, to ten test guinea pigs to induce sensitization. The water for injection was used for similar injection and occlusively patched to five control guinea pigs. Following a recovery period, animals received a challenge patch with 10% CR SB32N2. The skin sensitization reactions were scored at approximately 24 and 48 hours after patch removal. At the end of study, body weight increase was observed in all animals. During 48 hours after challenge exposure, no treated animals showed sensitization to the CR SB32N2. Under the conditions of this study, CR SB32N2 caused weak sensitization in guinea pigs.
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