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Diss Factsheets

Administrative data

Endpoint:
genetic toxicity in vitro
Type of information:
(Q)SAR
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The study has been judged as reliable with restrictions since it was conducted by a QSAR model.
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other: QSAR
Title:
In-vivo mutagenicity (Micronucleus) alerts by ISS
Author:
QSAR Toolbox 3.3.5.17
Year:
2016
Bibliographic source:
QSAR Toolbox 3.3.5.17
Report date:
2016

Materials and methods

Principles of method if other than guideline:
QSAR Toolbox was used to determine the mechanistic profile of the substance.

Test material

Constituent 1
Chemical structure
Reference substance name:
Salt of 4-azidobutan-1-amine and (7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl)methanesulfonic acid
EC Number:
943-084-2
Molecular formula:
C14H26N4O4S
IUPAC Name:
Salt of 4-azidobutan-1-amine and (7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl)methanesulfonic acid
Constituent 2
Reference substance name:
NCCCCN=[N+]=[N-].CC1(C)C2CCC1(CS(O)(=O)=O)C(=O)C2
IUPAC Name:
NCCCCN=[N+]=[N-].CC1(C)C2CCC1(CS(O)(=O)=O)C(=O)C2

Results and discussion

Test results
Genotoxicity:
other: inconclusive

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information):
other: inconclusive

QSAR Toolbox identifies a structural alert of concern; in particular for in vivo mutagenicity (Micronucleus) alerts by ISS this altert is "Azide and triazine groups".