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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
eye irritation: in vitro / ex vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Performed to recognised methods 2014

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2014
Report date:
2014

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 437 (Bovine Corneal Opacity and Permeability Test Method for Identifying Ocular Corrosives and Severe Irritants)
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Reference substance name:
(2-aminoethyl)(2-{[(2E)-3-methoxy-2-methyl-3-(octylsulfanyl)prop-2-en-1-yl]amino}ethyl)amine; 11-methoxy-12-methyl-3-(prop-1-en-2-yl)-2-oxa-4,7,10,14,17-pentaazanonadecan-19-amine; 2-methyl-3-(octylsulfanyl)-N-{2-[(2-{2-[(octylsulfanyl)methyl]propanamido}ethyl)amino]ethyl}propanamide; 3-({2-[(2-aminoethyl)amino]ethyl}amino)-2-methyl-N-{2-[(2-{2-[(octylsulfanyl)methyl]propanamido}ethyl)amino]ethyl}propanamide; N-{2-[(2-aminoethyl)amino]ethyl}-2-methyl-3-(octylsulfanyl)propanamide
EC Number:
929-305-5
IUPAC Name:
(2-aminoethyl)(2-{[(2E)-3-methoxy-2-methyl-3-(octylsulfanyl)prop-2-en-1-yl]amino}ethyl)amine; 11-methoxy-12-methyl-3-(prop-1-en-2-yl)-2-oxa-4,7,10,14,17-pentaazanonadecan-19-amine; 2-methyl-3-(octylsulfanyl)-N-{2-[(2-{2-[(octylsulfanyl)methyl]propanamido}ethyl)amino]ethyl}propanamide; 3-({2-[(2-aminoethyl)amino]ethyl}amino)-2-methyl-N-{2-[(2-{2-[(octylsulfanyl)methyl]propanamido}ethyl)amino]ethyl}propanamide; N-{2-[(2-aminoethyl)amino]ethyl}-2-methyl-3-(octylsulfanyl)propanamide
Test material form:
other: Liquid
Details on test material:
Identification: Reaction product of n-octylmercaptan, methyl methacrylate (MMA) and diethylenetriamine (DETA)
Appearance/Physical State: Amber viscous liquid
Purity: > 99%

Test system

Vehicle:
unchanged (no vehicle)
Amount / concentration applied:
0.75 ml undiluted test material
Duration of treatment / exposure:
10 minute exposure
Observation period (in vivo):
120 minute observation, incubated at 32 C

Results and discussion

In vivo

Results
Irritation parameter:
cornea opacity score
Basis:
other:
Score:
82.4
Reversibility:
other: not applicable
Irritant / corrosive response data:
A corneal score of 82.4 was assigned

Any other information on results incl. tables

The corneas treated with the test item were clear post treatment and cloudy post incubation. The corneas treated with the negative control item were clear post treatment and post incubation. The corneas treated with the positive control item were cloudy post treatment and post incubation.

Applicant's summary and conclusion

Interpretation of results:
Category 1 (irreversible effects on the eye)
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The results of this study have identified the test item as Category 1. UN GHS or EU CLP
Causes serious eye damage.
Executive summary:

The results of this study have identified the test item as Category 1. UN GHS or EU CLP Causes serious eye damage.