Cobalt di(acetate)

Long-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

long-term toxicity to aquatic invertebrates

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Comparable to guideline study with acceptable restrictions. No analytical dose verification.

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Effects of various metals on survival, growth, reproduction, and metabolism of Daphnia magna

Author:

Biesinger KE, Christensen GM

Year:

1972

Bibliographic source:

J Fish Res Board Can 29(12): 1691-1700

Reference 2

Reference Type:

secondary source

Title:

Cobalt and inorganic cobalt compounds

Author:

WHO

Year:

2006

Bibliographic source:

CICAD 69

Materials and methods

Principles of method if other than guideline:

Method: Chronic test (reproduction)

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Cobalt dichloride, hexahydrate

IUPAC Name:

Cobalt dichloride, hexahydrate

Constituent 2

Reference substance name:

7791-13-1

EC Number:

616-574-6

Cas Number:

7791-13-1

IUPAC Name:

7791-13-1

Details on test material:

Analytical purity: reagent grade

Sampling and analysis

Analytical monitoring:

no

Test solutions

Vehicle:

no

Test organisms

Test organisms (species):

Daphnia magna

Details on test organisms:

TEST ORGANISM
- Common name: Water flea
- Source: laboratory clone, originally obtained from the University of Michigan
- Age at study initiation (mean and range, SD): 12±12h
- Feeding during test: yes

Study design

Test type:

semi-static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

21 d

Test conditions

Hardness:

appr. 45 mg/l (total)

Test temperature:

18±1°C

pH:

7.74±0.3

Dissolved oxygen:

approx. 9 mg/L

Results and discussion

Effect concentrations

Duration:

21 d

Dose descriptor:

NOEC

Effect conc.:

0.005 mg/L

Nominal / measured:

nominal

Conc. based on:

element

Remarks:

Co

Basis for effect:

other: reproduction

Any other information on results incl. tables

LC50 = 0.021 mg/l Co 
Reproductive impairment 50% = 0.012 mg/l Co 
Reproductive impairment 16%= 0.01 mg/l Co 

The NOEC was calculated according to TGD Part 2 (2003)
LOEC > 10 and < 20% effect: NOEC = LOEC/2.