Registration Dossier

Administrative data

First-aid measures

General
Take persons to a safe place. Observe self-protection when administering first aid. Always seek medical advice in the event of contact with this substance.

After Swallowing
GE SDS: Give approximately 50 ml of hard liquor, such as whisky, providing the subject is fully conscious. Otherwise do not give anything by mouth. Do not induce vomiting. Obtain medical attention immediately.
(GESTIS: If accidentally swallowed rinse the mouth with plenty of water (only if the person is conscious). Do not give fatty oils and milk. Induce vomiting.).

After Inhalation
Remove to fresh air. Give artificial respiration if not breathing. If breathing is difficult, oxygen may be given by qualified personnel. If conscious, administer Glucocorticoid aerosol (cortison). Obtain medical attention.

After Skin Contact
Immediately remove contaminated clothing and shoes. Wash skin thoroughly with soap and water for at least fifteen minutes. Obtain medical attention immediately (if signs of irritation are observed obtain medical attention). Wash clothing before re-use. Discard contaminated leather articles such as shoes and belts.

After Eye Contact
Immediately flush eyes with water and continue washing for at least 15 minutes. Obtain medical attention without delay, preferably from an opthalmologist.

Notes to physician
Product may hydrolyze on contact with body fluids in the gastrointestinal tract to produce additional methanol: therefore, consider the signs/symptoms of methanol poisoning and also observe the known latency period of several days.

GESTIS:
Notes to physician:
Symptoms for severe poisoning:

Eyes: severe danger by liquid splashes, aerosols, vapors at potentially weak primary symptomatology (conjunctival alteration). Resorption and subsequent hydrolysis result in severe corneal lesions (desquamation).

Skin: Irritation, potentially resorptive effects at intense long-term contact

Inhalation: all transitional states possible ranging from weak symptoms of irritation to severe lung impairment (haemorrhage, toxic oedema) proportional to concentration

Ingestion: potentially severe irritation effects to contacted mucous membranes (progress reports not available), symptoms after resorption (no experience with human beings): somnolence of unclear genesis

Notes for first aid of physicians:
In case of severe intoxication eye treatment is of highest priority beside the maintenance of vital functions. Experiences with tetramethoxysilane (which is also extremely toxic to eyes) show that corneal lesions following medium exposure were reversible, if immediately treated with cortisone while conducting infection prophylaxis in parallel. The same procedure should be applied for trimethoxysilane. For the lung oedema prophylaxis a potentially long latency period of up to two days has to be considered. Beside dosed aerosol it is strongly recommended to apply glucocorticoides.

Strict bed rest is required, infection prophylaxis is recommended. If needed oxygen has to be applied. In case of spasticity in the bronchial section Theophyllin or Orciprenalin have to be applied. After ingestion of trimethoxysilane the major portion of the pollutant has to be eliminated by gastric lavage (intubation). Subsequently activated coal and a saline laxative are to be applied considering the potential severe damage of the mucous membranes.

Recommendations:
Inform physician about substance/product and applied treatment. Works doctors should train employees who handle trimethoxysilane to use gas tight safety glasses. Animal tests have revealed that silicium compounds with a similar structure (e.g. tetramethoxysilane), which however hydrolyze more rapidly, have a kidney damaging effect and also affect liver, blood and heart circulation. Testing of these parameters is important when poisoning with trimethoxysilane occurred.

Fire-fighting measures

Suitable extinguishing media, large fires: alcohol-type foam or universal-type foam
Suitable extinguishing media, small fires: carbon dioxide, dry chemical
Unsuitable extinguishing media: none

Special fire fighting procedures
Do not direct a solid stream of water or foam into hot, burning pools: this may cause frothing and increase fire intensity. Cool affected containers.

Special protective equipment for firefighters
Self-contained breathing apparatus. Body covering protective clothing.

Unusual fire or explosion hazards
Vapours form from this product and may travel or be moved by air currents and ignited by pilot lights, other flames, sparks, heaters, electrical equipment, static discharges or other ignition sources at locations distant from product handling point. Vapour may be ignited by static sparks. Use proper bonding and grounding during material transfer.

Accidental release measures

Extinguish and do not turn on any ignition source until the area is determined to be free from fire or explosion hazards.
Evacuate and secure contaminated area.
Enter contaminated area only with suiatable Personal protective equipment.
Avoid contact with eyes and skin. Avoid contact with liquid and vapours. (Stay upwind at all times).
Environmental precautions
Prevent run-off to surface water, drains or sewers and soil. Contain any fluid run-off using suitable materials (for example, soil). Retain contaminated water or extinguishing water.

Methods for cleaning up
Cover with absorbent (Kieselgur, Vermiculit, Sand) or contain. Collect for disposal.

Handling and storage

Advice on safe handling
Do not swallow. Do not get into eyes, on skin, on clothing. Avoid breathing vapour, aerosol and mist. Electrically bond and ground all containers and equipment. Use with adequate ventilation. Wash thoroughly after handling.

Ventilation
General (mechanical) room ventilation is expected to be satisfactory where this product is stored and handled in closed equipment. Special, local ventilation is needed at points where vapours can be expected to escape to the workplace air.

Other precautions
Releases hydrogen gas (flammable) on contact with strong acid or strong base. May release hydrogen on standing in container. Since this product can, under certain conditions, evolve hydogen gas, care should be taken to avoid exposure to flame, excessive heat and sparks. The evolution of hydrogen gas is accelerated by the presence of metals, such as lead (in solders) and zinc (in galvanised equipment), and alkalis. Care should, therefore, be taken to avoid contaminants in storage containers. Store containers in a well-ventilated area. Open them cautiously, in case they may be under slight pressure. Have good ventilation and suitable protective equipment in areas where containers will be opened.

Storage Requirements
Keep container closed. Keep away from heat, sparks and flame.

GESTIS:
Storage conditions:
Containers have to be clearly and permanently labelled.
Preferably keep in original container.
Fragile containers have to be placed in break-proof secondary containers.
Store cool.
Store dry.
Keep container at well ventilated place
Joint storage with the following substances is not allowed:
Pharmaceuticals, food, fodder including additives
Infectively, radioactive and explosive substances
Compressed, liquefied or dissolved gases
Spontaneously combustible substances.
Substances that form flammable gases in contact with water.
Organic peroxides
Oxidizing substances (according to the German Federal Technical Guideline Hazardous Substances, TRGS, 515)
Mixtures containing ammonium nitrate (according to TRGS 511)
Flammable solid substances (according to storage classes 4.1A and 4.1B)
Toxic and very toxic substances, which are not flammable
Combustible materials such as paper, cardboard, wood, foils

Joint storage of the following substances is permitted under specific conditions:
Spray cans
Oxidizing substances
Combustible solids
Corrosive substances in fragile containers
The substances must not be jointly stored with substance with which dangerous chemical reactions are possible

Transport information

Land transport (ADR/RID)

UN number:
9269
3286
3384
Shippingopen allclose all
Proper shipping name and description:
TRIMETHOXYSILANE (UN 9269)
Chemical name:
Trimethoxysilane
Language:
English
Proper shipping name and description:
Toxic by inhalation liquid, flammable, n.o.s. (UN 3384)
Chemical name:
Trimethoxysilane
Language:
English
Proper shipping name and description:
FLAMMABLE LIQUID, TOXIC, CORROSIVE, N.O.S. (UN 3286)
Chemical name:
Trimethoxysilane
Language:
English
Class:
6.1, 3 (UN 9269)
6.1, 3 (UN 3384)
3, 6.1, 8 (UN 3286)
Classification code:
663 (for UN 3384)
386 (for UN 3286)
Packaging group:
1 (all UN numbers)
Labels:
6.1, 3 (UN 9269)
6.1, 3 (UN 3384)
3, 6.1, 8 (UN 3286)
SpecialProvisionsopen allclose all

Inland waterway transport (ADN(R))

UN number:
9269
3384
3286
Shippingopen allclose all
Class:
6.1 ,3 (UN 9269)
6.1, 3 (UN 3384)
3, 6.1, 8 (UN 3286)
Packaging group:
1 (all UN numbers)
Labels:
6.1, 3 (UN 9269)
3, 6.1 (UN 3384)
3, 6.1, 8 (UN 3286)
Remarksopen allclose all

Marine transport (IMDG)

UN number:
9269
3384
3286
Proper shipping name and description:
TRIMETHOXYSILANE (UN 9269)
Toxic by inhalation liquid, flammable, n.o.s. (UN 3384)
FLAMMABLE LIQUID, TOXIC, CORROSIVE, N.O.S. (UN 3286)
Chemical name:
Trimethoxysilane
Class:
6.1 (UN 9269)
6.1, 3 (UN 3384)
3, 6.1, 8 (UN 3286)
Packaging group:
1 (all UN numbers)
EmS code:
3-04 (UN 3286)
Labels:
6.1, 3 (UN 9269)
6.1 (UN 3384)
3, 6.1, 8 (UN 3286)
Remarksopen allclose all

Air transport ICAO/IATA

UN number:
FORBIDDEN BY AIR
Remarksopen allclose all
SpecialProvisionsopen allclose all

Exposure controls / personal protection

Wear appropriate protective gloves, clothing anf goggles.

Respiratory protection
Self-contained breathing apparatus in high vapour concentrations.

Hand protection/protective gloves
PVC-coated

Eye protection
Monogoggles

Other Protective Equipment
Chemical Apron, Eye Bath, Safety Shower

Stability and reactivity

Stability
This product may be unstable.

Conditions to avoid
Do not store at temperatures >30 degrees C. Disproportionation may occur.

Incompatible materials
Avoid contact with: Lewis acids. Aqueous acids. Aqueous bases. Amines. Reacts with water or moisture to form: Methanol. Free methanol leads to dehydrocondensation. Reacts with water or alcohol in the presence of acids or bases to release hydrogen (flammable gas). Avoid steel or stainless steel containers which lead to disproportionation.

Hazardous combustion products
Burning can produce the following combustion products: Oxides of carbon. Oxides of silicon.
Carbon monoxide is highly toxic if inhaled; carbon dioxide in sufficient concentrations can act as an asphyxiant. Acute overexposure to the products of combustion may result in irritation of the respiratory tract.

Polymerisation
May Occur.
Conditions to avoid
Stable under normal conditions. Polymerisation can occur in the presence of: Catalytic noble metals. Alkalis

Disposal considerations

Dilute with an inert solvent. Incinerate in a furnace where permittted under national and local regulations.
GESTIS:
Dangerous waste according to the Waste-Inventory-Ordinance (AVV)
Wastes have to be disposed of following the local requirements if no recycling is feasible
Collection of small amounts of waste:
Collect in containers for toxic and flammable compounds
Do not dispose of in sink or waste bin
Waste collection containers have to be labelled showing the type of waste and the hazard labels of the waste
Keep waste containers at a well-ventilated place
Dispose of via certified disposal company