Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 224-832-0 | CAS number: 4511-42-6
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- genetic toxicity in vitro
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Review publication
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Safety assessment of glycolic acid, ammonium, calcium, potassium, and sodium glycolate, methyl, ethyl, ptopyl, and butyl glycolate, and lactic acid, ammonium calcium, potassium, sodium, and TEA-lactate, methyl, ethyl, isopropyl, and butyl lactate, and
- Author:
- Andersen, F.A.
- Year:
- 1 997
- Bibliographic source:
- Cosmetic Ingredients Review, final report. International Journal of Toxicology, Vol.17, Suppl.1.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- other
- GLP compliance:
- no
- Type of assay:
- other: Review on several mutagenicity studies with lactic acid and some lactates
Test material
- Reference substance name:
- L-(+)-lactic acid
- EC Number:
- 201-196-2
- EC Name:
- L-(+)-lactic acid
- Cas Number:
- 79-33-4
- IUPAC Name:
- 2-hydroxypropanoic acid
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- other: various
- Metabolic activation:
- with and without
- Test concentrations with justification for top dose:
- Various
Results and discussion
Test results
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Remarks on result:
- other: other: Various
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
The results of 11 studies are reviewed.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
Lactic acid is considered not genotoxic.
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