Registration Dossier
Registration Dossier
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EC number: 215-687-4 | CAS number: 1344-09-8
Health surveillance data
Administrative data
- Endpoint:
- health surveillance data
- Type of information:
- other: case report
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Ulcerative contact dermatitis caused by sodium silicate. Coexistence of primary irritant contact dermatitis and contact urticaria.
- Author:
- Tanaka T et al.
- Year:
- 1 982
- Bibliographic source:
- Arch. Dermatol. 118, 518-520
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
- Study type:
- human medical data
- Endpoint addressed:
- skin sensitisation
- Principles of method if other than guideline:
- Case study observations
- GLP compliance:
- no
Test material
- Reference substance name:
- Silicic acid, sodium salt
- EC Number:
- 215-687-4
- EC Name:
- Silicic acid, sodium salt
- Cas Number:
- 1344-09-8
- Molecular formula:
- Na2O x (SiO2)n with Molar Ratio (MR) (SiO2/Na2O): 1.5 – 4
- IUPAC Name:
- sodium hydroxy(oxo)silanolate
- Details on test material:
- 20 % sodium silicate solution of unknown molar ratio.
Constituent 1
Method
- Type of population:
- occupational
- Ethical approval:
- not applicable
Results and discussion
- Results:
- A fifty-seven year old dyer was regularly exposed at work to 20 % sodiumsilicate solution of unknown molar ratio. The man had recurrent ulcerative lesions on his left hand over a period of two years. The ulcers were associated with chronic eczematous changes resulting from primary irritant contact dermatitis to sodium silicate, as indicated by a positive patch test. The man also had another type of cutaneous reaction to sodium silicate, contact urticaria. An immediate wheal and flare reaction was seen fifteen minutes after the application of sodium silicate to a scratch test site. Such a response was not seen in healthy control subjects.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
