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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study according to OECD Guideline, but only 1 animal tested. No information on purity of test substance.

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1985
Reference Type:
review article or handbook
Title:
Unnamed
Year:
2004
Report date:
2004

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
yes
Remarks:
only one animal tested
GLP compliance:
yes
Remarks:
Inveresk Research International

Test material

Constituent 1
Chemical structure
Reference substance name:
Silicic acid, potassium salt
EC Number:
215-199-1
EC Name:
Silicic acid, potassium salt
Cas Number:
1312-76-1
Molecular formula:
K2O x (SiO2)n with Molar Ratio (MR) (SiO2/K2O): 0.5 – 5 (with exception of MR = 1)
IUPAC Name:
potassium hydroxysilanoylolate
Details on test material:
SOURCE: EKA Kemi AB
PURITY: Not reported
IMPURITY/ADDITIVE/ETC.: Not reported
ANY OTHER INFORMATION: 36 wt% Potassium Waterglass. Molar ratio 2.0

Test animals

Species:
rabbit
Strain:
New Zealand White
Details on test animals or test system and environmental conditions:
TEST ANIMALS: 
- Sex: female 
- Source: Cheshire Rabbit Farms Ltd.
- Age: approx. 11 weeks
- Weight at study initiation: 2.3 - 3.0 kg 

Test system

Type of coverage:
semiocclusive
Preparation of test site:
shaved
Vehicle:
water
Controls:
not specified
Amount / concentration applied:
Concentration: 36 T49-004:wt%; 0.5 mL
Duration of treatment / exposure:
4 hour(s)
Observation period:
5 days
Number of animals:
1
Details on study design:
- Removal of test substance: yes (washed away with water)
- Scoring system: according to Draize
- Examination time points: 1, 24, 48, 72 hours and 5 days

Results and discussion

In vivo

Results
Irritation parameter:
primary dermal irritation index (PDII)
Time point:
other: 1, 24, 48, 72 hours and 5 days
Score:
1
Reversibility:
other: Test sample only elicited transient erythema which was clear by day 5.

Any other information on results incl. tables

AVERAGE SCORE:
- Erythema: 1
- Edema: 0

No further details on "results" available.


Applicant's summary and conclusion

Interpretation of results:
slightly irritating
Remarks:
Migrated information