Registration Dossier
Registration Dossier
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EC number: 215-199-1 | CAS number: 1312-76-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study according to OECD Guideline, but only 1 animal tested. No information on purity of test substance.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- only one animal tested
- GLP compliance:
- yes
- Remarks:
- Inveresk Research International
Test material
- Reference substance name:
- Silicic acid, potassium salt
- EC Number:
- 215-199-1
- EC Name:
- Silicic acid, potassium salt
- Cas Number:
- 1312-76-1
- Molecular formula:
- K2O x (SiO2)n with Molar Ratio (MR) (SiO2/K2O): 0.5 – 5 (with exception of MR = 1)
- IUPAC Name:
- potassium hydroxysilanoylolate
- Details on test material:
- SOURCE: EKA Kemi AB
PURITY: Not reported
IMPURITY/ADDITIVE/ETC.: Not reported
ANY OTHER INFORMATION: 36 wt% Potassium Waterglass. Molar ratio 2.0
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS:
- Sex: female
- Source: Cheshire Rabbit Farms Ltd.
- Age: approx. 11 weeks
- Weight at study initiation: 2.3 - 3.0 kg
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- not specified
- Amount / concentration applied:
- Concentration: 36 T49-004:wt%; 0.5 mL
- Duration of treatment / exposure:
- 4 hour(s)
- Observation period:
- 5 days
- Number of animals:
- 1
- Details on study design:
- - Removal of test substance: yes (washed away with water)
- Scoring system: according to Draize
- Examination time points: 1, 24, 48, 72 hours and 5 days
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Time point:
- other: 1, 24, 48, 72 hours and 5 days
- Score:
- 1
- Reversibility:
- other: Test sample only elicited transient erythema which was clear by day 5.
Any other information on results incl. tables
AVERAGE SCORE:
- Erythema: 1
- Edema: 0
No further details on "results" available.
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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